Evidence map›Paper›PMID 20535321›Full record

ArticleJournal of neurogastroenterology and motility2010

Nonerosive Reflux Disease (NERD) - An Update.

Tiberiu Hershcovici, Ronnie Fass

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurogastroenterology and motility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07584096 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Inspiratory Muscle Training on Clinical Symptom Severity and Quality of Life in Patients With Non-erosive Reflux Disease: A Randomized Controlled Trial

TypeinterventionalSponsorIzmir University of EconomicsRan2026 to 2027Enrolled60ConditionsNon-erosive Reflux Disease (NERD)ArmsInspiratory Muscle Training (IMT), Sham IMT
NCT07707011 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Potassium Competitive Acid Blocker (PCAB) Test-Guided vs Physiologic Test-Guided Treatment in Patients With Typical Reflux Symptoms: A Randomized Non-inferiority Trial

TypeinterventionalSponsorMahidol UniversityRan2026 to 2027Enrolled120ConditionsGERD, Acid Reflux, TreatmentArmsPCAB-test guided
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  16. Insight into global burden of gastroesophageal reflux disease: Understanding its reach and impact.World journal of gastrointestinal pharmacology and therapeutics · 2025
    Review
  17. Review
  18. Article
  19. Role of Endoscopy in Motility Disorders of Upper Gastrointestinal Tract.Journal of neurogastroenterology and motility · 2023
    Review
  20. Dynorphin participates in interaction between depression and non-erosive reflux disease.Esophagus : official journal of the Japan Esophageal Society · 2023
    Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tiberiu HershcoviciThe Neuroenteric Clinical Research Group, Section of Gastroenterology, Southern Arizona VA Health Care System, Tucson, Arizona, USA.
Ronnie Fass

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recognizing nonerosive reflux disease (NERD) as a distinct presentation of gastroesophageal reflux disease (GERD) was one of the most important developments in the field of GERD in the last decade. Whilst the definition of NERD has not changed significantly over the years, the disorder accounts for the majority of the GERD patients and those who failed proton pump inhibitor (PPI) treatment. Recent developments in NERD focused primarily on understanding the pathophysiology and natural history. The introduction of esophageal impedance + pH has led to the assessment of other forms of gastroesophageal reflux in causing NERD. Therapeutic modalities still focus on acid suppression, but there is growing recognition that other therapeutic strategies should be considered in NERD.

Indexed as

Gastroesophageal reflux diseaseNonerosive reflux diseaseProton pump inhibitor

Identifiers

PMID20535321
PMCPMC2879816

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.