ArticleJournal of virology2010
Divergent evolution of norovirus GII/4 by genome recombination from May 2006 to February 2009 in Japan.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Article
- Genomic diversity and comparative phylogenomic analysis of genus Norovirus.Scientific reports · 2025Article
- Biological Specimen Banking as a Time Capsule to Explore the Temporal Dynamics of Norovirus Epidemiology.Viruses · 2023Article
- Epidemiology, Clinical Features, and Unusual Complications of Norovirus Infection in Taiwan: What We Know after Rotavirus Vaccines.Pathogens (Basel, Switzerland) · 2022Review
- Mass Spectrometry-Based System for Identifying and Typing Norovirus Major Capsid Protein VP1.Viruses · 2021Article
- Review
- Genome-wide analyses of human noroviruses provide insights on evolutionary dynamics and evidence of coexisting viral populations evolving under recombination constraints.PLoS pathogens · 2021Article
- Long-term dynamics ofPeerJ · 2021Article
- Identification of two divergent swine Noroviruses detected at the slaughterhouse in North East Italy.Porcine health management · 2020Article
- Molecular Evolution of the Protease Region in Norovirus Genogroup II.Frontiers in microbiology · 2019Article
- Estimating the Asymptomatic Ratio of Norovirus Infection During Foodborne Outbreaks With Laboratory Testing in Japan.Journal of epidemiology · 2018Article
- Deletion of a 197-Amino-Acid Region in the N-Terminal Domain of Spike Protein Attenuates Porcine Epidemic Diarrhea Virus in Piglets.Journal of virology · 2017Article
- Evolutionary Constraints on the Norovirus Pandemic Variant GII.4_2006b over the Five-Year Persistence in Japan.Frontiers in microbiology · 2017Article
- Static and Evolving Norovirus Genotypes: Implications for Epidemiology and Immunity.PLoS pathogens · 2017Article
- Delayed norovirus epidemic in the 2009-2010 season in Japan: potential relationship with intensive hand sanitizer use for pandemic influenza.Epidemiology and infection · 2016Article
- Article
- Temporal Evolutionary Dynamics of Norovirus GII.4 Variants in China between 2004 and 2015.PloS one · 2016Article
- Epidemiology and molecular characteristics of norovirus GII.4 Sydney outbreaks in Taiwan, January 2012-December 2013.Journal of medical virology · 2015Article
- Molecular evolution of the VP1, VP2, and VP3 genes in human rhinovirus species C.Scientific reports · 2015Article
- The spatial diffusion of norovirus epidemics over three seasons in Tokyo.Epidemiology and infection · 2015Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Norovirus GII/4 is a leading cause of acute viral gastroenteritis in humans. We examined here how the GII/4 virus evolves to generate and sustain new epidemics in humans, using 199 near-full-length GII/4 genome sequences and 11 genome segment clones from human stool specimens collected at 19 sites in Japan between May 2006 and February 2009. Phylogenetic studies demonstrated outbreaks of 7 monophyletic GII/4 subtypes, among which a single subtype, termed 2006b, had continually predominated. Phylogenetic-tree, bootscanning-plot, and informative-site analyses revealed that 4 of the 7 GII/4 subtypes were mosaics of recently prevalent GII/4 subtypes and 1 was made up of the GII/4 and GII/12 genotypes. Notably, single putative recombination breakpoints with the highest statistical significance were constantly located around the border of open reading frame 1 (ORF1) and ORF2 (P <or= 0.000001), suggesting outgrowth of specific recombinant viruses in the outbreaks. The GII/4 subtypes had many unique amino acids at the time of their outbreaks, especially in the N-term, 3A-like, and capsid proteins. Unique amino acids in the capsids were preferentially positioned on the outer surface loops of the protruding P2 domain and more abundant in the dominant subtypes. These findings suggest that intersubtype genome recombination at the ORF1/2 boundary region is a common mechanism that realizes independent and concurrent changes on the virion surface and in viral replication proteins for the persistence of norovirus GII/4 in human populations.
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