ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Endogenous histamine facilitates long-term potentiation in the hippocampus during walking.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Histamine HScientific reports · 2019Article
- Prenatal Alcohol Exposure Increases Histamine HAlcoholism, clinical and experimental research · 2018Article
- Histamine H3 Receptor Antagonist Prevents Memory Deficits and Synaptic Plasticity Disruption Following Isoflurane Exposure.CNS neuroscience & therapeutics · 2017Article
- Superficial Layer-Specific Histaminergic Modulation of Medial Entorhinal Cortex Required for Spatial Learning.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.The international journal of neuropsychopharmacology · 2015Article
- Differential effects of the histamine H(3) receptor agonist methimepip on dentate granule cell excitability, paired-pulse plasticity and long-term potentiation in prenatal alcohol-exposed rats.Alcoholism, clinical and experimental research · 2014Article
- H₁ but not H₂ histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- About sleep's role in memory.Physiological reviews · 2013Review
- Histamine receptor expression, hippocampal plasticity and ammonia in histidine decarboxylase knockout mice.Cellular and molecular neurobiology · 2012Article
- The likelihood of cognitive enhancement.Pharmacology, biochemistry, and behavior · 2011Review
- Long-Term Potentiation at CA3-CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress.Frontiers in aging neuroscience · 2011Article
- Electrophysiological correlates of sleep homeostasis in freely behaving rats.Progress in brain research · 2011Review
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Long-term potentiation (LTP) in hippocampal CA1 depends on the behavioral state of LTP induction. We hypothesize that histaminergic activity in the septohippocampal system, which is active during walking compared with other behavioral states, is responsible for the behavioral dependence of LTP. Field basal-dendritic EPSPs of CA1 pyramidal cells were recorded in freely behaving rats, and LTP was induced by a single 200 Hz stimulation train (0.5 s duration). Basal-dendritic LTP was facilitated when induced during walking compared with awake immobility (IMM) or rapid-eye-movement sleep. The facilitation of basal-dendritic LTP during walking was abolished by lesion of tuberomammillary nucleus (TMN) neurons with orexin-saporin or by intramedial-septal infusion of the H(1) histaminergic blocker triprolidine but not the H(2) histaminergic blocker cimetidine. Conversely, histamine infusion in the medial septum enhanced the basal-dendritic LTP induced during IMM to a magnitude similar to that induced during walking. Basal-dendritic LTP induced during walking was not further enhanced by intraseptal histamine infusion. Combined with the previous result that behavior-dependent LTP is mediated by cholinergic septohippocampal neurons, we conclude that the facilitation of basal-dendritic LTP in CA1 during walking was mediated by TMN histaminergic afferents acting on H(1) receptors in the medial septum, which may then enhance cholinergic and noncholinergic inputs to the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.