ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Acute disruption of the NMDA receptor subunit NR1 in the honeybee brain selectively impairs memory formation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 73 citations in OpenAlex.
- Never underestimate honeybees: Their exceptionally diverse adaptive strategies.Journal of advanced research · 2026Review
- Sulfoxaflor Impairs Bumblebee Memory Across Moderate and Extreme Temperatures.Ecology and evolution · 2025Article
- Behavioral and genetic correlates of heterogeneity in learning performance in individual honeybees, Apis mellifera.PloS one · 2024Article
- Honey bee functional genomics using symbiont-mediated RNAi.Nature protocols · 2023Review
- In-vivo egfp expression in the honeybee Apis mellifera induced by electroporation and viral expression vector.PloS one · 2022Article
- Olfactory coding in honeybees.Cell and tissue research · 2021Review
- Neural shutdown under stress: an evolutionary perspective on spreading depolarization.Journal of neurophysiology · 2020Review
- Review
- RNA-seq reveals disruption of gene regulation when honey bees are caged and deprived of hive conditions.The Journal of experimental biology · 2019Article
- Identification of the neurotransmitter profile of AmFoxP expressing neurons in the honeybee brain using double-label in situ hybridization.BMC neuroscience · 2018Article
- Detection of Phospholipase C Activity in the Brain Homogenate from the Honeybee.Journal of visualized experiments : JoVE · 2018Article
- Pharmacologic inhibition of phospholipase C in the brain attenuates early memory formation in the honeybee (Biology open · 2018Article
- Phylogenetic analysis of ionotropic L-glutamate receptor genes in the Bilateria, with special notes on Aplysia californica.BMC evolutionary biology · 2017Article
- Age-associated increase of the active zone protein Bruchpilot within the honeybee mushroom body.PloS one · 2017Article
- Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Activation of NO-cGMP Signaling Rescues Age-Related Memory Impairment in Crickets.Frontiers in behavioral neuroscience · 2016Article
- Differentially expressed genes linked to natural variation in long-term memory formation in Cotesia parasitic wasps.Frontiers in behavioral neuroscience · 2015Article
- Emerging strategies for RNA interference (RNAi) applications in insects.Bioengineered · 2015Review
- Molecular mechanisms underlying formation of long-term reward memories and extinction memories in the honeybee (Apis mellifera).Learning & memory (Cold Spring Harbor, N.Y.) · 2014Review
- A proboscis extension response protocol for investigating behavioral plasticity in insects: application to basic, biomedical, and agricultural research.Journal of visualized experiments : JoVE · 2014Article
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6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory formation is a continuous process composed of multiple phases that can develop independently from each other. These phases depend on signaling pathways initiated after the activation of receptors in different brain regions. The NMDA receptor acts as a sensor of coincident activity between neural inputs, and, as such, its activation during learning is thought to be crucial for various forms of memory. In this study, we inhibited the expression of the NR1 subunit of the NMDA receptor in the honeybee brain using RNA interference. We show that the disruption of the subunit expression in the mushroom body region of the honeybee brain during and shortly after appetitive learning selectively impaired memory. Although the formation of mid-term memory and early long-term memory was impaired, late long-term memory was left intact. This indicates that late long-term memory formation differs in its dependence on NMDA receptor activity from earlier memory phases.
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