ArticleMolecular biology of the cell2010
Glycogen synthase kinase-3 is required for efficient Dictyostelium chemotaxis.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Regulation of mTORC2 Signaling.Genes · 2020Review
- Glycogen synthase kinase 3 (GSK-3) controls T-cell motility and interactions with antigen presenting cells.BMC research notes · 2020Article
- Article
- Phosphorylated Rho-GDP directly activates mTORC2 kinase towards AKT through dimerization with Ras-GTP to regulate cell migration.Nature cell biology · 2019Article
- Curcumin affects gene expression and reactive oxygen species via a PKA dependent mechanism in Dictyostelium discoideum.PloS one · 2017Article
- A cAMP and CREB-mediated feed-forward mechanism regulates GSK3β in polycystic kidney disease.Journal of molecular cell biology · 2016Article
- Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells.Bioscience reports · 2016Article
- PP2A/B56 and GSK3/Ras suppress PKB activity during Dictyostelium chemotaxis.Molecular biology of the cell · 2015Article
- Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes.Cellular and molecular life sciences : CMLS · 2014Review
- Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer.Science (New York, N.Y.) · 2014Article
- Initiation of multicellular differentiation in Dictyostelium discoideum is regulated by coronin A.Molecular biology of the cell · 2014Article
- Glycogen Synthase Kinase 3 influences cell motility and chemotaxis by regulating PI3K membrane localization in Dictyostelium.Development, growth & differentiation · 2013Article
- Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility.Molecular biology of the cell · 2013Article
- Regulation of aggregate size and pattern by adenosine and caffeine in cellular slime molds.BMC developmental biology · 2012Article
- Prolyl oligopeptidase, inositol phosphate signalling and lithium sensitivity.CNS & neurological disorders drug targets · 2011Review
- Combinatorial cell-specific regulation of GSK3 directs cell differentiation and polarity in Dictyostelium.Development (Cambridge, England) · 2011Article
- Aberrant spindle dynamics and cytokinesis in Dictyostelium discoideum cells that lack glycogen synthase kinase 3.European journal of cell biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Glycogen synthase kinase-3 (GSK3) is a highly conserved protein kinase that is involved in several important cell signaling pathways and is associated with a range of medical conditions. Previous studies indicated a major role of the Dictyostelium homologue of GSK3 (gskA) in cell fate determination during morphogenesis of the fruiting body; however, transcriptomic and proteomic studies have suggested that GSK3 regulates gene expression much earlier during Dictyostelium development. To investigate a potential earlier role of GskA, we examined the effects of loss of gskA on cell aggregation. We find that cells lacking gskA exhibit poor chemotaxis toward cAMP and folate. Mutants fail to activate two important regulatory signaling pathways, mediated by phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) and target of rapamycin complex 2 (TORC2), which in combination are required for chemotaxis and cAMP signaling. These results indicate that GskA is required during early stages of Dictyostelium development, in which it is necessary for both chemotaxis and cell signaling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.