ArticleMolecular biology of the cell2010
The retinoblastoma protein modulates Tbx2 functional specificity.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- TBX2 acts as a potent transcriptional silencer of tumour suppressor genes through interaction with the CoREST complex to sustain the proliferation of breast cancers.Nucleic acids research · 2022Article
- TBX2 controls a proproliferative gene expression program in melanoma.Genes & development · 2021Article
- The Evolution of Melanoma - Moving beyond Binary Models of Genetic Progression.The Journal of investigative dermatology · 2020Review
- Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease.Cellular and molecular life sciences : CMLS · 2019Article
- Article
- Effect of silencing the T‑Box transcription factor TBX2 in prostate cancer PC3 and LNCaP cells.Molecular medicine reports · 2017Article
- Modeling Developmental and Tumorigenic Aspects of Trilateral Retinoblastoma via Human Embryonic Stem Cells.Stem cell reports · 2017Article
- Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2-WNT Signaling Axis.Cancer research · 2017Article
- Cell-specific Kaiso (ZBTB33) Regulation of Cell Cycle through Cyclin D1 and Cyclin E1.The Journal of biological chemistry · 2016Article
- New insights into signalling-pathway alterations in rhabdomyosarcoma.British journal of cancer · 2015Review
- Putative Breast Cancer Driver Mutations in TBX3 Cause Impaired Transcriptional Repression.Frontiers in oncology · 2015Article
- The T-box gene family: emerging roles in development, stem cells and cancer.Development (Cambridge, England) · 2014Review
- Genetic analysis of the TBX2 gene promoter in indirect inguinal hernia.Hernia : the journal of hernias and abdominal wall surgery · 2014Article
- Distinct tissue-specific requirements for the zebrafish tbx5 genes during heart, retina and pectoral fin development.Open biology · 2014Article
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- Elevated T-box 2 in infantile hemangioma stem cells maintains an adipogenic differentiation-competent state.Dermato-endocrinology · 2013Article
- The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs.Journal of virology · 2013Article
- TBX2 expression is regulated by PAX3 in the melanocyte lineage.Pigment cell & melanoma research · 2013Article
- An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.The Journal of pathology · 2012Article
- Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease.PLoS computational biology · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Tbx2 is a member of a large family of transcription factors defined by homology to the T-box DNA-binding domain. Tbx2 plays a key role in embryonic development, and in cancer through its capacity to suppress senescence and promote invasiveness. Despite its importance, little is known of how Tbx2 is regulated or how it achieves target gene specificity. Here we show that Tbx2 specifically associates with active hypophosphorylated retinoblastoma protein (Rb1), a known regulator of many transcription factors involved in cell cycle progression and cellular differentiation, but not with the Rb1-related proteins p107 or p130. The interaction with Rb1 maps to a domain immediately carboxy-terminal to the T-box and enhances Tbx2 DNA binding and transcriptional repression. Microarray analysis of melanoma cells expressing inducible dominant-negative Tbx2, comprising the T-box and either an intact or mutated Rb1 interaction domain, shows that Tbx2 regulates the expression of many genes involved in cell cycle control and that a mutation which disrupts the Rb1-Tbx2 interaction also affects Tbx2 target gene selectivity. Taken together, the data show that Rb1 is an important determinant of Tbx2 functional specificity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.