ArticleCerebral cortex (New York, N.Y. : 1991)2010
Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 1 of them a synthesis that pooled it.
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106 citing papers in PubMed, 1 synthesis or guideline pooled it, 177 citations in OpenAlex.
- An MRI-Based, Data-Driven Model of Cortical Laminar Connectivity.Neuroinformatics · 2021Pooled it
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- Thalamocortical feedback selectively controls pyramidal neuron excitability.Nature communications · 2025Article
- Immediately following the onset of active whisking, the input layer of barrel cortex exhibits a transient period of increased excitability that depends on prior experience.bioRxiv : the preprint server for biology · 2025Article
- Combining nanobody labeling with STED microscopy reveals input-specific and layer-specific organization of neocortical synapses.PLoS biology · 2025Article
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- Neuronal composition of processing modules in human V1: laminar density for neuronal and non-neuronal populations and a comparison with macaque.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Cell density quantification of high resolution Nissl images of the juvenile rat brain.Frontiers in neuroanatomy · 2024Article
- Simulation-based inference for efficient identification of generative models in computational connectomics.PLoS computational biology · 2023Article
- Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics.Cell reports · 2023Article
- Targeting operational regimes of interest in recurrent neural networks.PLoS computational biology · 2023Article
- Interpretable machine learning approach for neuron-centric analysis of human cortical cytoarchitecture.Scientific reports · 2023Article
- Mapping thalamic innervation to individual L2/3 pyramidal neurons and modeling their 'readout' of visual input.Nature neuroscience · 2023Article
- Cortical Representation of Touch in Silico.Neuroinformatics · 2022Article
46 more citing papers are in PubMed but not listed here.
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6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This is the second article in a series of three studies that investigate the anatomical determinants of thalamocortical (TC) input to excitatory neurons in a cortical column of rat primary somatosensory cortex (S1). Here, we report the number and distribution of NeuN-positive neurons within the C2, D2, and D3 TC projection columns in P27 rat somatosensory barrel cortex based on an exhaustive identification of 89,834 somata in a 1.15 mm(3) volume of cortex. A single column contained 19,109 ± 444 neurons (17,560 ± 399 when normalized to a standard-size projection column). Neuron density differences along the vertical column axis delineated "cytoarchitectonic" layers. The resulting neuron numbers per layer in the average column were 63 ± 10 (L1), 2039 ± 524 (L2), 3735 ± 905 (L3), 4447 ± 439 (L4), 1737 ± 251 (L5A), 2235 ± 99 (L5B), 3786 ± 168 (L6A), and 1066 ± 170 (L6B). These data were then used to derive the layer-specific action potential (AP) output of a projection column. The estimates confirmed previous reports suggesting that the ensembles of spiny L4 and thick-tufted pyramidal neurons emit the major fraction of APs of a column. The number of APs evoked in a column by a sensory stimulus (principal whisker deflection) was estimated as 4441 within 100 ms post-stimulus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.