SynthesisThe Journal of clinical endocrinology and metabolism2010
OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.
Synthesis in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone.PLoS genetics · 2010Pooled it
- Gene-gene and gene-environment interactions ofFrontiers in aging · 2026Article
- Correlation of metabolic markers and OPG gene mutations with bone mass abnormalities in postmenopausal women.Journal of orthopaedic surgery and research · 2024Review
- Endocrine Health and Health Care Disparities in the Pediatric and Sexual and Gender Minority Populations: An Endocrine Society Scientific Statement.The Journal of clinical endocrinology and metabolism · 2023Article
- Bone mineral density in high-level endurance runners: Part B-genotype-dependent characteristics.European journal of applied physiology · 2022Article
- Article
- Factors influencing peak bone mass gain.Frontiers of medicine · 2021Review
- Associations of LRP5 Gene With Bone Mineral Density, Bone Turnover Markers, and Fractures in the Elderly With Osteoporosis.Frontiers in endocrinology · 2020Article
- Opportunities and Challenges in Functional Genomics Research in Osteoporosis: Report From a Workshop Held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020.Frontiers in endocrinology · 2020Review
- pQCT bone geometry and strength: population epidemiology and concordance in Australian children aged 11-12 years and their parents.BMJ open · 2019Article
- Article
- Genetics of Bone Mass in Childhood and Adolescence: Effects of Sex and Maturation Interactions.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Article
- Association analysis between g.18873C>T and g.27522G>A genetic polymorphisms of OPG and bone mineral density in Chinese postmenopausal women.BioMed research international · 2014Article
- Novel candidate genes putatively involved in stress fracture predisposition detected by whole-exome sequencing.Genetics research · 2014Article
- The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.Endocrine · 2013Article
- Developmental origins of genotype-phenotype correlations in chronic diseases of old age.Aging and disease · 2012Article
- "Single nucleotide polymorphisms of the OPG/RANKL system genes in primary hyperparathyroidism and their relationship with bone mineral density".BMC medical genetics · 2011Article
- Influence of polymorphisms in the RANKL/RANK/OPG signaling pathway on volumetric bone mineral density and bone geometry at the forearm in men.Calcified tissue international · 2011Article
- The ESR1 (6q25) locus is associated with calcaneal ultrasound parameters and radial volumetric bone mineral density in European men.PloS one · 2011Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
contextSeveral single-nucleotide polymorphisms (SNPs) have been reliably associated with areal bone mineral density (aBMD) in genome-wide association studies of mostly older subjects.
objectiveWe aimed to test those SNPs for an association with peripheral quantitative computed tomography (pQCT) bone measures in two young cohorts. DESIGN AND STUDY
participantsWe genotyped nine SNPs from the most promising aBMD candidates in a cohort of 15-yr-olds [in the Avon Longitudinal Study of Parents and Children (ALSPAC)] and carried out association analysis with several tibial pQCT measures to determine whether these candidates were important during adolescent growth and which particular skeletal parameters each of the candidates were acting upon. We also carried out a metaanalysis of the SNPs for association with cortical bone mineral density (BMDC) in ALSPAC and a similar male-only study (Gothenburg Osteoporosis and Obesity Determinants).
resultsIn the ALSPAC cohort, we found a significant association between RANK SNP (rs3018362) and BMDC but not any of the other pQCT bone measures. In the metaanalysis, we found the OPG SNP (rs4355801) and the RANK SNP (rs3018362) to be significantly associated with BMDC. We also found suggestive evidence of an association between the MARK3 SNP (rs2010281) and BMDC but with a direction of effect opposite to that previously reported.
conclusionThe association of genes from the RANK/RANKL/OPG pathway and BMDC provides new insight into how this system might affect the skeleton, confirming it to be associated with volumetric cortical bone density but observing no relationship with bone size.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.