ArticleProceedings. Biological sciences2010
Genetic variation in the cellular response of Daphnia magna (Crustacea: Cladocera) to its bacterial parasite.
Article in Proceedings. Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Transgenerational pathogen effects: Maternal pathogen exposure reduces offspring fitness.Ecology · 2025Article
- A web-based histology atlas for the freshwater sentinel species Daphnia magna.The Science of the total environment · 2025Article
- Differential gene expression in response to fungal pathogen exposure in the aquatic invertebrate,Ecology and evolution · 2023Article
- Review
- Genotype specificity among hosts, pathogens, and beneficial microbes influences the strength of symbiont-mediated protection.Evolution; international journal of organic evolution · 2017Article
- Costs of CRISPR-Cas-mediated resistance in Streptococcus thermophilus.Proceedings. Biological sciences · 2015Article
- Genetic architecture of resistance in Daphnia hosts against two species of host-specific parasites.Heredity · 2015Article
- Starvation reveals the cause of infection-induced castration and gigantism.Proceedings. Biological sciences · 2014Article
- Disentangling the interaction among host resources, the immune system and pathogens.Ecology letters · 2014Article
- Article
- The expression and evolution of virulence in multiple infections: the role of specificity, relative virulence and relative dose.BMC evolutionary biology · 2013Article
- Daphnia magna shows reduced infection upon secondary exposure to a pathogen.Biology letters · 2012Article
- The cellular immune response of Daphnia magna under host-parasite genetic variation and variation in initial dose.Evolution; international journal of organic evolution · 2012Article
- Disentangling the influence of parasite genotype, host genotype and maternal environment on different stages of bacterial infection in Daphnia magna.Proceedings. Biological sciences · 2012Article
- Epidemiology of a Daphnia-multiparasite system and its implications for the red queen.PloS one · 2012Article
- Candidate innate immune system gene expression in the ecological model Daphnia.Developmental and comparative immunology · 2011Article
- Evolutionary ecotoxicology of pesticide resistance: a case study in Daphnia.Ecotoxicology (London, England) · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Linking measures of immune function with infection, and ultimately, host and parasite fitness is a major goal in the field of ecological immunology. In this study, we tested for the presence and timing of a cellular immune response in the crustacean Daphnia magna following exposure to its sterilizing endoparasite Pasteuria ramosa. We found that D. magna possesses two cell types circulating in the haemolymph: a spherical one, which we call a granulocyte and an irregular-shaped amoeboid cell first described by Metchnikoff over 125 years ago. Daphnia magna mounts a strong cellular response (of the amoeboid cells) just a few hours after parasite exposure. We further tested for, and found, considerable genetic variation for the magnitude of this cellular response. These data fostered a heuristic model of resistance in this naturally coevolving host-parasite interaction. Specifically, the strongest cellular responses were found in the most susceptible hosts, indicating resistance is not always borne from a response that destroys invading parasites, but rather stems from mechanisms that prevent their initial entry. Thus, D. magna may have a two-stage defence--a genetically determined barrier to parasite establishment and a cellular response once establishment has begun.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.