ArticleProceedings of the National Academy of Sciences of the United States of America2010
Dictyostelium amoebae and neutrophils can swim.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- 4D Time-lapse imaging of cell dynamics in human alveolar tissue by label-free higher harmonic generation microscopy.Journal of translational medicine · 2026Article
- Biophysical modeling identifies an optimal hybrid amoeboid-mesenchymal mechanism for maximal T cell migration speeds.Cell reports · 2026Article
- Biophysical modeling identifies an optimal hybrid amoeboid-mesenchymal mechanism for maximal T cell migration speeds.bioRxiv : the preprint server for biology · 2025Article
- Chemotactic navigation in robotic swimmers via reset-free hierarchical reinforcement learning.Nature communications · 2025Article
- Cell deformations generated by stochastic actomyosin waves drive in vivo random-walk swimming migration.Journal of cell science · 2025Article
- Neutrophil extracellular traps capture the human pathogen, Candida albicans, in blood and delay hyphal transformation.Journal of leukocyte biology · 2025Article
- Convergent pairs of highly transcribed genes restrict chromatin looping in Dictyostelium discoideum.Nucleic acids research · 2025Article
- Cell Membrane Tension Gradients, Membrane Flows, and Cellular Processes.Physiology (Bethesda, Md.) · 2024Review
- Trackoscope: A low-cost, open, autonomous tracking microscope for long-term observations of microscale organisms.PloS one · 2024Article
- Naive T lymphocytes chemotax long distance to CCL21 but not to a source of bioactive S1P.iScience · 2023Article
- Mesenchymal Migration on Adhesive-Nonadhesive Alternate Surfaces in Macrophages.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- 3D single cell migration driven by temporal correlation between oscillating force dipoles.eLife · 2022Article
- Cells responding to chemoattractant on a structured substrate.Biophysical journal · 2022Article
- WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues.Developmental cell · 2022Article
- Moving through a changing world: Single cell migration in 2D vs. 3D.Frontiers in cell and developmental biology · 2022Review
- Amoeboid migration in health and disease: Immune responsesFrontiers in cell and developmental biology · 2022Review
- Self-organization in amoeboid motility.Frontiers in cell and developmental biology · 2022Review
- Leukocyte transmigration and longitudinal forward-thrusting force in a microfluidic Transwell device.Biophysical journal · 2021Article
- Transcytosis in the development and morphogenesis of epithelial tissues.The EMBO journal · 2021Review
- Amoeboid Swimming Is Propelled by Molecular Paddling in Lymphocytes.Biophysical journal · 2020Article
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No grant is acknowledged in the PubMed record.
Abstract
Animal cells migrating over a substratum crawl in amoeboid fashion; how the force against the substratum is achieved remains uncertain. We find that amoebae and neutrophils, cells traditionally used to study cell migration on a solid surface, move toward a chemotactic source while suspended in solution. They can swim and do so with speeds similar to those on a solid substrate. Based on the surprisingly rapidly changing shape of amoebae as they swim and earlier theoretical schemes for how suspended microorganisms can migrate (Purcell EM (1977) Life at low Reynolds number. Am J Phys 45:3-11), we suggest the general features these cells use to gain traction with the medium. This motion requires either the movement of the cell's surface from the cell's front toward its rear or protrusions that move down the length of the elongated cell. Our results indicate that a solid substratum is not a prerequisite for these cells to produce a forward thrust during movement and suggest that crawling and swimming are similar processes, a comparison we think is helpful in understanding how cells migrate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.