ArticleProceedings of the National Academy of Sciences of the United States of America2010
Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 42 citations in OpenAlex.
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- Evolutionary patterns of chimeric retrogenes in Oryza species.Scientific reports · 2019Article
- In vivo recombination of Saccharomyces eubayanus maltose-transporter genes yields a chimeric transporter that enables maltotriose fermentation.PLoS genetics · 2019Article
- AtFusionDB: a database of fusion transcripts in Arabidopsis thaliana.Database : the journal of biological databases and curation · 2019Article
- Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba.PLoS genetics · 2017Article
- Holding it together: rapid evolution and positive selection in the synaptonemal complex of Drosophila.BMC evolutionary biology · 2016Article
- Multispecies Analysis of Expression Pattern Diversification in the Recently Expanded Insect Ly6 Gene Family.Molecular biology and evolution · 2015Article
- Repeated evolution of chimeric fusion genes in the β-globin gene family of laurasiatherian mammals.Genome biology and evolution · 2014Article
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- Evolution of S-domain receptor-like kinases in land plants and origination of S-locus receptor kinases in Brassicaceae.BMC evolutionary biology · 2013Article
- Recurrent rearrangement during adaptive evolution in an interspecific yeast hybrid suggests a model for rapid introgression.PLoS genetics · 2013Article
- Evolution at the subgene level: domain rearrangements in the Drosophila phylogeny.Molecular biology and evolution · 2012Article
- Chimeric genes as a source of rapid evolution in Drosophila melanogaster.Molecular biology and evolution · 2012Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Chimeric genes, which form through the genomic fusion of two protein-coding genes, are a significant source of evolutionary novelty in Drosophila melanogaster. However, the propensity of chimeric genes to produce adaptive phenotypic changes is not fully understood. Here, we describe the chimeric gene Quetzalcoatl (Qtzl; CG31864), which formed in the recent past and swept to fixation in D. melanogaster. Qtzl arose through a duplication on chromosome 2L that united a portion of the mitochondrially targeted peptide CG12264 with a segment of the polycomb gene escl. The 3' segment of the gene, which is derived from escl, is inherited out of frame, producing a unique peptide sequence. Nucleotide diversity is drastically reduced and site frequency spectra are significantly skewed surrounding the duplicated region, a finding consistent with a selective sweep on the duplicate region containing Qtzl. Qtzl has an expression profile that largely resembles that of escl, with expression in early pupae, adult females, and male testes. However, expression patterns appear to have been decoupled from both parental genes during later embryonic development and in head tissues of adult males, indicating that Qtzl has developed a distinct regulatory profile through the rearrangement of different 5' and 3' regulatory domains. Furthermore, misexpression of Qtzl suppresses defects in the formation of the neuromuscular junction in larvae, demonstrating that Qtzl can produce phenotypic effects in cells. Together, these results show that chimeric genes can produce structural and regulatory changes in a single mutational step and may be a major factor in adaptive evolution.
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