Trial reportBMC cancer2010
Physical Activity during Cancer Treatment (PACT) Study: design of a randomised clinical trial.
Trial report in BMC cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Physical activity interventions for disease-related physical and mental health during and following treatment in people with non-advanced colorectal cancer.The Cochrane database of systematic reviews · 2020Pooled it
- Exercise for women receiving adjuvant therapy for breast cancer.The Cochrane database of systematic reviews · 2016Pooled it
- Recommendations for high-priority research on cancer-related fatigue in children and adults.Journal of the National Cancer Institute · 2013Guideline
- Multidisciplinary rehabilitation for follow-up of women treated for breast cancer.The Cochrane database of systematic reviews · 2012Pooled it
- Exercise interventions on health-related quality of life for people with cancer during active treatment.The Cochrane database of systematic reviews · 2012Pooled it
- Eight-year follow-up of patient-reported outcomes in patients with breast cancer participating in exercise studies during chemotherapy.Journal of cancer survivorship : research and practice · 2026Trial
- The adapted Zelen was a feasible design to trial exercise in myeloma survivors.Journal of clinical epidemiology · 2020Trial
- Trial
- Trial
- A prospective, multicenter pilot study to investigate the feasibility and safety of a 1-year controlled exercise training after adjuvant chemotherapy in colorectal cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Trial
- Trial
- Effects of an 18-week exercise programme started early during breast cancer treatment: a randomised controlled trial.BMC medicine · 2015Trial
- Feasibility of a supervised and home-based tailored exercise intervention in head and neck cancer patients during chemoradiotherapy.European journal of cancer care · 2022Article
- Combined aerobic and resistance training improves physical capacity in women treated for gynecological cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Four-year effects of exercise on fatigue and physical activity in patients with cancer.BMC medicine · 2018Article
- Exercise Training and Cardiovascular Health in Cancer Patients.Current oncology reports · 2018Review
- The "Interval Walking in Colorectal Cancer" (I-WALK-CRC) study: Design, methods and recruitment results of a randomized controlled feasibility trial.Contemporary clinical trials communications · 2018Article
- Wearable activity monitors in oncology trials: Current use of an emerging technology.Contemporary clinical trials · 2018Review
- Development of a computer-tailored physical activity intervention for prostate and colorectal cancer patients and survivors: OncoActive.BMC cancer · 2017Article
- Searching for maintenance in exercise interventions for cancer survivors.Journal of cancer survivorship : research and practice · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFatigue is a major problem of cancer patients. Thirty percent of cancer survivors report serious fatigue three years after finishing treatment. There is evidence that physical exercise during cancer treatment reduces fatigue. This may also lead to an improvement of quality of life. Such findings may result in a decrease of healthcare related expenditures and societal costs due to sick leave. However, no studies are known that investigated these hypotheses. Therefore, the primary aim of our study is to assess the effect of exercise during cancer treatment on reducing complaints of fatigue and on reducing health service utilisation and sick leave. METHODS/
designThe Physical Activity during Cancer Treatment study is a multicentre randomised controlled trial in 150 breast and 150 colon cancer patients undergoing cancer treatment. Participants will be randomised to an exercise or a control group. In addition to the usual care, the exercise group will participate in an 18-week supervised group exercise programme. The control group will be asked to maintain their habitual physical activity pattern. Study endpoints will be assessed after 18 weeks (short term) and after 9 months (long term). Validated questionnaires will be used. PRIMARY OUTCOME: fatigue (Multidimensional Fatigue Inventory and Fatigue Quality List) and cost-effectiveness, health service utilisation and sick leave. Secondary outcome: health related quality of life (European Organisation Research and Treatment of Cancer-Quality of Life questionnaire-C30, Short Form 36 healthy survey), impact on functioning and autonomy (Impact on functioning and autonomy questionnaire), anxiety and depression (Hospital Anxiety and Depression Scale), physical fitness (aerobic peak capacity, muscle strength), body composition and cognitive-behavioural aspects. To register health service utilisation and sick leave, participants will keep diaries including the EuroQuol-5D. Physical activity level will be measured using the Short Questionnaire to Assess Health-Enhancing Physical Activity and will be monitored with an exercise log and a pedometer. DISCUSSION: This study investigates the (cost)-effectiveness of exercise during adjuvant treatment of patients with breast or colon cancer. If early physical exercise proves to be (cost) effective, establishing standardised physical exercise programmes during cancer treatment will be planned.
trial registrationCurrent Controlled trials ISRCTN43801571, Dutch Trial Register NTR2138.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.