ArticleJournal of the American Geriatrics Society2010
Gerontologic biostatistics: the statistical challenges of clinical research with older study participants.
Article in Journal of the American Geriatrics Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Efficacy and effectiveness as aspects of cluster randomized trials with nursing home residents: methodological insights from a pneumonia prevention trial.Contemporary clinical trials · 2012Trial
- Gerontologic Biostatistics and Data Science: Aging Research in the Era of Big Data.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Review
- Transparent transdisciplinary reporting in geriatric research using the EQUATOR Network.Journal of the American Geriatrics Society · 2022Article
- Factors influencing the statistical planning, design, conduct, analysis and reporting of trials in health care: A systematic review.Contemporary clinical trials communications · 2022Review
- Methodological challenges in pragmatic trials in Alzheimer's disease and related dementias: Opportunities for improvement.Clinical trials (London, England) · 2022Article
- Approaches to Optimize Medication Data Analysis in Clinical Cohort Studies.Journal of the American Geriatrics Society · 2020Article
- Statistical Considerations for Embedded Pragmatic Clinical Trials in People Living with Dementia.Journal of the American Geriatrics Society · 2020Article
- Genetics of physiological dysregulation: findings from the long life family study using joint models.Aging · 2020Article
- Cores for geriatric oncology infrastructure in the Cancer and Aging Research Group: Biostatistics, epidemiology, and research design (the analytics core).Journal of geriatric oncology · 2020Article
- Coprescribing of Benzodiazepines and Opioids in Older Adults: Rates, Correlates, and National Trends.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Patterns and Perceived Benefits of Utilizing Seven Major Complementary Health Approaches in U.S. Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Attention to Individuals: Mixed Methods for N-of-1 Health Care Interventions.Journal of mixed methods research · 2017Article
- Translational research in immune senescence: assessing the relevance of current models.Seminars in immunology · 2012Review
- Hearing, mobility, and pain predict mortality: a longitudinal population-based study.Journal of clinical epidemiology · 2012Article
- Mixed Methods for the Interpretation of Longitudinal Gerontologic Data: Insights From Philosophical Hermeneutics.Journal of mixed methods research · 2011Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The medical and personal circumstances of older persons present challenges for designing and analyzing clinical research studies in which they participate. These challenges that elderly study samples present are not unique, but they are sufficiently distinctive to warrant deliberate and systematic attention. Their distinctiveness originates in the multifactorial etiologies of geriatric health syndromes and the multiple morbidities accruing with aging at the end of life. The objective of this article is to identify a set of statistical challenges arising in research with older persons that should be considered conjointly in the practice of clinical research and addressed systematically in the training of biostatisticians intending to work with gerontologists, geriatricians, and older study participants. The statistical challenges include design and analytical strategies for multicomponent interventions, multiple outcomes, state transition models, floor and ceiling effects, missing data, and mixed methods. The methodological and pedagogical themes of this article will be integrated by a description of a proposed subdiscipline of "gerontologic biostatistics" and supported by the introduction of new set of statistical resources for researchers working in this area. These conceptual and methodological resources have been developed in the context of several collaborating Claude D. Pepper Older Americans Independence Centers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.