ArticleChemMedChem2010
HTS and rational drug design to generate a class of 5-HT(2C)-selective ligands for possible use in schizophrenia.
Article in ChemMedChem, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- "Selective" serotonin 5-HTBiochemical pharmacology · 2022Review
- Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HTMolecules (Basel, Switzerland) · 2019Article
- Identification of Optically Active Pyrimidine Derivatives as Selective 5-HTMolecules (Basel, Switzerland) · 2017Article
- Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models.Journal of medicinal chemistry · 2016Article
- We Need 2C but Not 2B: Developing Serotonin 2C (5-HT2C) Receptor Agonists for the Treatment of CNS Disorders.ChemMedChem · 2015Article
- Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.Journal of medicinal chemistry · 2015Article
- Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation.PloS one · 2013Article
- Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings.Journal of neurodevelopmental disorders · 2012Article
- Rational Drug Design Leading to the Identification of a Potent 5-HT(2C) Agonist Lacking 5-HT(2B) Activity.ACS medicinal chemistry letters · 2011Article
- A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging.Science (New York, N.Y.) · 2011Article
- Serotonin receptors and heart valve disease--it was meant 2B.Pharmacology & therapeutics · 2011Review
- Irving Page Lecture: 5-HT(2A) serotonin receptor biology: interacting proteins, kinases and paradoxical regulation.Neuropharmacology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
PubMed holds no abstract for this paper.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.