ArticleChembiochem : a European journal of chemical biology2010
Going forward laterally: transmembrane passage of hydrophobic molecules through protein channel walls.
Article in Chembiochem : a European journal of chemical biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- The Arsenal of Aromatic Degrading Bacteria: How They Sense, Chase, Adapt and Destroy Environmental Pollutants.Microbial biotechnology · 2026Review
- Study and Modification of the Polycyclic Aromatic Hydrocarbon Degradation Gene Cluster inMicroorganisms · 2025Article
- Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light.Pharmaceutical biology · 2024Review
- Extracellular vesicles of Norway spruce contain precursors and enzymes for lignin formation and salicylic acid.Plant physiology · 2024Article
- Early hyperlipidemia triggers metabolomic reprogramming with increased SAH, increased acetyl-CoA-cholesterol synthesis, and decreased glycolysis.Redox biology · 2023Article
- Rhizobial migration toward roots mediated by FadL-ExoFQP modulation of extracellular long-chain AHLs.The ISME journal · 2023Article
- A Novel FadL Homolog, AltL, Mediates Transport of Long-Chain Alkanes and Fatty Acids in Acinetobacter venetianus RAG-1.Applied and environmental microbiology · 2022Article
- Lipid Transport Across Bacterial Membranes.Annual review of cell and developmental biology · 2022Review
- Oil Bioremediation in the Marine Environment of Antarctica: A Review and Bibliometric Keyword Cluster Analysis.Microorganisms · 2021Review
- Uptake of monoaromatic hydrocarbons during biodegradation by FadL channel-mediated lateral diffusion.Nature communications · 2020Article
- Enhanced Triacylglycerol Metabolism Contributes to Efficient Oil Utilization and High-Level Production of Salinomycin in Streptomyces albus ZD11.Applied and environmental microbiology · 2020Article
- Passive membrane transport of lignin-related compounds.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- Differential Protein Expression During Growth on Medium Versus Long-Chain Alkanes in the Obligate Marine Hydrocarbon-Degrading BacteriumFrontiers in microbiology · 2018Article
- Insertion of proteins and lipopolysaccharide into the bacterial outer membrane.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Global Dynamic Proteome Study of a Pellicle-forming Acinetobacter baumannii Strain.Molecular & cellular proteomics : MCP · 2017Article
- Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model.Nature reviews. Microbiology · 2016Review
- The anaerobic linalool metabolism in Thauera linaloolentis 47 Lol.BMC microbiology · 2016Article
- Modulating the import of medium-chain alkanes in E. coli through tuned expression of FadL.Journal of biological engineering · 2016Article
- Crystal structure of a COG4313 outer membrane channel.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Regular phospholipid bilayers do not pose efficient barriers for the transport of hydrophobic molecules. The outer membrane (OM) surrounding Gram-negative bacteria is a nontypical, asymmetric bilayer with an outer layer of lipopolysaccharide (LPS). The sugar molecules of the LPS layer prevent spontaneous diffusion of hydrophobic molecules across the OM. As regular OM channels such as porins do not allow passage of hydrophobic molecules, specialized OM transport proteins are required for their uptake. Such proteins, exemplified by channels of the FadL family, transport their substrates according to a lateral diffusion mechanism. Here, substrates diffuse from the lumen of the beta-barrel laterally into the OM, through a stable opening in the wall of the barrel. In this way, the lipopolysaccharide barrier is bypassed and, by depositing the substrates into the OM, a driving force for uptake is provided. Lateral diffusion through protein channel walls also occurs in alpha-helical inner membrane proteins, and could represent a widespread mechanism for proteins that transport and interact with hydrophobic substrates.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.