ArticleGenesis (New York, N.Y. : 2000)2010
Analysis of a zebrafish behavioral mutant reveals a dominant mutation in atp2a1/SERCA1.
Article in Genesis (New York, N.Y. : 2000), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Fgf8, a gene knockout that leads to intermuscular bones-reduced of crucian carp (Carassius auratus), acts as a potentially regulatory factor in osteogenic development.Fish physiology and biochemistry · 2026Article
- Defects of the Glycinergic Synapse in Zebrafish.Frontiers in molecular neuroscience · 2016Review
- Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish.Frontiers in pharmacology · 2014Review
- Recording field potentials from zebrafish larvae during escape responses.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2014Article
- Pseudomyotonia in Romagnola cattle caused by novel ATP2A1 mutations.BMC veterinary research · 2012Article
- Mutation of zebrafish dihydrolipoamide branched-chain transacylase E2 results in motor dysfunction and models maple syrup urine disease.Disease models & mechanisms · 2012Article
- Behavioral genetics in larval zebrafish: learning from the young.Developmental neurobiology · 2012Review
- Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms.Disease models & mechanisms · 2012Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Zebrafish embryos demonstrate robust swimming behavior, which consists of smooth, alternating body bends. In contrast, several motility mutants have been identified that perform sustained, bilateral trunk muscle contractions which result in abnormal body shortening. Unlike most of these mutants, accordion (acc)(dta5) demonstrates a semidominant effect: Heterozygotes exhibit a distinct but less severe phenotype than homozygotes. Using molecular-genetic mapping and candidate gene analysis, we determined that acc(dta5) mutants harbor a novel mutation in atp2a1, which encodes SERCA1, a calcium pump important for muscle relaxation. Previous studies have shown that eight other acc alleles compromise SERCA1 function, but these alleles were all reported to be recessive. Quantitative behavioral assays, complementation testing, and analysis of molecular models all indicate that the acc(dta5) mutation diminishes SERCA1 function to a greater degree than other acc alleles through either haploinsufficient or dominant-negative molecular mechanisms. Since mutation of human ATP2A1 results in Brody disease, an exercise-induced impairment of muscle relaxation, acc(dta5) mutants may provide a particularly sensitive model of this disorder.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.