ArticleThe Journal of comparative neurology2010
Development-based compartmentalization of the Drosophila central brain.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- A connectome and analysis of the adulteLife · 2020Pooled it
- The Drosophila adult brain: short overview of structure, function, and resources Graphical Review Paper.Current research in insect science · 2025Review
- The conserved RNA-binding protein Imp is required for the specification and function of olfactory navigation circuitry in Drosophila.Current biology : CB · 2024Article
- Hierarchical Modular Structure of theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Lineages to circuits: the developmental and evolutionary architecture of information channels into the central complex.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Review
- The RNA-binding protein, Imp specifies olfactory navigation circuitry and behavior inbioRxiv : the preprint server for biology · 2023Article
- Asymmetric activity of NetrinB controls laterality of the Drosophila brain.Nature communications · 2023Article
- The Neuromodulatory Basis of Aggression: Lessons From the Humble Fruit Fly.Frontiers in behavioral neuroscience · 2022Review
- Developmentally Arrested Precursors of Pontine Neurons Establish an Embryonic Blueprint of the Drosophila Central Complex.Current biology : CB · 2019Article
- Ensheathing cells utilize dynamic tiling of neuronal somas in development and injury as early as neuronal differentiation.Neural development · 2018Article
- Neuronal Constituents and Putative Interactions Within theFrontiers in neural circuits · 2018Article
- Structure and development of the subesophageal zone of the Drosophila brain. I. Segmental architecture, compartmentalization, and lineage anatomy.The Journal of comparative neurology · 2018Article
- Development of the anterior visual input pathway to the Drosophila central complex.The Journal of comparative neurology · 2017Article
- A conserved plan for wiring up the fan-shaped body in the grasshopper and Drosophila.Development genes and evolution · 2017Article
- Visual Input to the Drosophila Central Complex by Developmentally and Functionally Distinct Neuronal Populations.Current biology : CB · 2017Article
- Developmental analysis of the dopamine-containing neurons of the Drosophila brain.The Journal of comparative neurology · 2017Article
- Crucial roles of Pox neuro in the developing ellipsoid body and antennal lobes of the Drosophila brain.PloS one · 2017Article
- Lineage-associated tracts defining the anatomy of the Drosophila first instar larval brain.Developmental biology · 2015Article
- Origin and development of neuropil glia of the Drosophila larval and adult brain: Two distinct glial populations derived from separate progenitors.Developmental biology · 2015Article
- Hydroxyurea-mediated neuroblast ablation establishes birth dates of secondary lineages and addresses neuronal interactions in the developing Drosophila brain.Developmental biology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The neuropile of the Drosophila brain is subdivided into anatomically discrete compartments. Compartments are rich in terminal neurite branching and synapses; they are the neuropile domains in which signal processing takes place. Compartment boundaries are defined by more or less dense layers of glial cells as well as long neurite fascicles. These fascicles are formed during the larval period, when the approximately 100 neuronal lineages that constitute the Drosophila central brain differentiate. Each lineage forms an axon tract with a characteristic trajectory in the neuropile; groups of spatially related tracts congregate into the brain fascicles that can be followed from the larva throughout metamorphosis into the adult stage. Here we provide a map of the adult brain compartments and the relevant fascicles defining compartmental boundaries. We have identified the neuronal lineages contributing to each fascicle, which allowed us to compare compartments of the larval and adult brain directly. Most adult compartments can be recognized already in the early larval brain, where they form a "protomap" of the later adult compartments. Our analysis highlights the morphogenetic changes shaping the Drosophila brain; the data will be important for studies that link early-acting genetic mechanisms to the adult neuronal structures and circuits controlled by these mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.