ArticleThe Journal of comparative neurology2010
Mice deficient in brain-derived neurotrophic factor have altered development of gastric vagal sensory innervation.
Article in The Journal of comparative neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Peripheral tissue BDNF expression is affected by promoter IV defect and enriched environments in mice: negative hippocampus-intestine and positive thymus-serum-muscle correlations.Molecular medicine (Cambridge, Mass.) · 2025Article
- Article
- Ontogeny and Trophic Factor Sensitivity of Gastrointestinal Projecting Vagal Sensory Cell Types.eNeuro · 2023Article
- The model of litter size reduction induces long-term disruption of the gut-brain axis: An explanation for the hyperphagia of Wistar rats of both sexes.Physiological reports · 2022Article
- Innervation in organogenesis.Current topics in developmental biology · 2022Article
- Mapping of Extrinsic Innervation of the Gastrointestinal Tract in the Mouse Embryo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice.PloS one · 2019Article
- Drug Targets in Neurotrophin Signaling in the Central and Peripheral Nervous System.Molecular neurobiology · 2018Review
- You Are What You (First) Eat.Frontiers in human neuroscience · 2018Review
- Kif1bp loss in mice leads to defects in the peripheral and central nervous system and perinatal death.Scientific reports · 2017Article
- Reduced intestinal brain-derived neurotrophic factor increases vagal sensory innervation of the intestine and enhances satiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The gastrointestinal tract microbiome and potential link to Alzheimer's disease.Frontiers in neurology · 2014Review
- Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-D-aspartate receptor subunits and D-serine.Neurochemistry international · 2013Article
- Vagal afferent controls of feeding: a possible role for gastrointestinal BDNF.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2013Review
- Mechanism of hyperphagia contributing to obesity in brain-derived neurotrophic factor knockout mice.Neuroscience · 2013Article
- Slit/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut.Developmental dynamics : an official publication of the American Association of Anatomists · 2013Article
- Early postnatal overnutrition: potential roles of gastrointestinal vagal afferents and brain-derived neurotrophic factor.Physiology & behavior · 2012Review
- Development of the vagal innervation of the gut: steering the wandering nerve.Neurogastroenterology and motility · 2011Review
- Molecular development of the extrinsic sensory innervation of the gastrointestinal tract.Autonomic neuroscience : basic & clinical · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vagal sensory neurons are dependent on neurotrophins for survival during development. Here, the contribution of brain-derived neurotrophic factor (BDNF) to survival and other aspects of gastric vagal afferent development was investigated. Post-mortem anterograde tracing with 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbo-cyanine perchlorate (DiI) was used to label selectively vagal projections to the stomach on postnatal days (P) 0, 3, 4, and 6 in wild types and heterozygous or homozygous BDNF mutants. Sampling sites distributed throughout the ventral stomach wall were scanned with a confocal microscope, and vagal axon bundles, single axons, putative mechanoreceptor precursors (intraganglionic laminar endings, IGLEs; intramuscular arrays, IMAs), and efferent terminals were quantified. Also, myenteric neurons, which are innervated by IGLEs, were stained with cuprolinic blue and counted. Quantitative comparisons across wild-type stomach compartments demonstrated that the adult distribution of IMAs was not present at P0 but began to form by P3-6. Among all the quantified elements, at P0, only IGLE density was significantly different in homozygous mutants compared with wild types, exhibiting a 50% reduction. Also, antrum innervation appeared disorganized, and some putative IMA precursors had truncated telodendria. At P3-6, the effect on IGLEs had recovered, the disorganization of antrum innervation had partially recovered, and some IMA telodendria were still truncated. The present results suggest that gastric IGLEs are among the vagal sensory neurons dependent on BDNF for survival or axon guidance. Alternatively, BDNF deficiency may delay gastric IGLE development. Also, BDNF may contribute to IMA differentiation and patterning of antral vagal innervation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.