ArticleAge (Dordrecht, Netherlands)2011
Caloric restriction or resveratrol supplementation and ageing in a non-human primate: first-year outcome of the RESTRIKAL study in Microcebus murinus.
Article in Age (Dordrecht, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial.The American journal of clinical nutrition · 2020Trial
- Dietary restriction in aging and longevity.Nature aging · 2026Review
- Resveratrol does not mimic the positive effects of calorie restriction on lifespan in Microcebus murinus.Communications biology · 2025Article
- A vegetable fat-based diet delays psychomotor and cognitive development compared with maternal dairy fat intake in infant gray mouse lemurs.Communications biology · 2024Article
- An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome.Nature communications · 2024Article
- Molecular Liver Fingerprint Reflects the Seasonal Physiology of the Grey Mouse Lemur (International journal of molecular sciences · 2022Article
- Survival is reduced when endogenous period deviates from 24 h in a non-human primate, supporting the circadian resonance theory.Scientific reports · 2020Article
- Physiological and cognitive consequences of a daily 26 h photoperiod in a primateProceedings. Biological sciences · 2020Article
- Promoting healthspan and lifespan with caloric restriction in primates.Communications biology · 2019Article
- Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism.The Journal of nutritional biochemistry · 2018Article
- Biological Activities of Stilbenoids.International journal of molecular sciences · 2018Review
- Long-Term Resveratrol Supplementation as a Secondary Prophylaxis for Stroke.Oxidative medicine and cellular longevity · 2018Article
- Caloric restriction increases lifespan but affects brain integrity in grey mouse lemur primates.Communications biology · 2018Article
- Plasma Amyloid Is Associated with White Matter and Subcortical Alterations and Is Modulated by Age and Seasonal Rhythms in Mouse Lemur Primates.Frontiers in aging neuroscience · 2018Article
- Dietary (Poly)phenols, Brown Adipose Tissue Activation, and Energy Expenditure: A Narrative Review.Advances in nutrition (Bethesda, Md.) · 2017Review
- Contributions of Nonhuman Primates to Research on Aging.Veterinary pathology · 2016Review
- Neurohormetic phytochemicals: An evolutionary-bioenergetic perspective.Neurochemistry international · 2015Review
- Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis.American journal of physiology. Cell physiology · 2014Article
- Article
- Effects of resveratrol on daily rhythms of locomotor activity and body temperature in young and aged grey mouse lemurs.Oxidative medicine and cellular longevity · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A life-long follow-up of physiological and behavioural functions was initiated in 38-month-old mouse lemurs (Microcebus murinus) to test whether caloric restriction (CR) or a potential mimetic compound, resveratrol (RSV), can delay the ageing process and the onset of age-related diseases. Based on their potential survival of 12 years, mouse lemurs were assigned to three different groups: a control (CTL) group fed ad libitum, a CR group fed 70% of the CTL caloric intake and a RSV group (200 mg/kg.day(-1)) fed ad libitum. Since this prosimian primate exhibits a marked annual rhythm in body mass gain during winter, animals were tested throughout the year to assess body composition, daily energy expenditure (DEE), resting metabolic rate (RMR), physical activity and hormonal levels. After 1 year, all mouse lemurs seemed in good health. CR animals showed a significantly decreased body mass compared with the other groups during long day period only. CR or RSV treatments did not affect body composition. CR induced a decrease in DEE without changes in RMR, whereas RSV induced a concomitant increase in DEE and RMR without any obvious modification of locomotor activity in both groups. Hormonal levels remained similar in each group. In summary, after 1 year of treatment CR and RSV induced differential metabolic responses but animals successfully acclimated to their imposed diets. The RESTRIKAL study can now be safely undertaken on a long-term basis to determine whether age-associated alterations in mouse lemurs are delayed with CR and if RSV can mimic these effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.