ReviewHeart failure reviews2010
Aging, telomeres and heart failure.
Review in Heart failure reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Age dependent associations of risk factors with heart failure: pooled population based cohort study.BMJ (Clinical research ed.) · 2021Pooled it
- The prevalence of frailty in heart failure: A systematic review and meta-analysis.International journal of cardiology · 2017Pooled it
- Research advances and application prospects of CAR-T therapy in the treatment of age-related diseases.Frontiers in immunology · 2026Review
- Post-traumatic stress disorder: evolving conceptualization and evidence, and future research directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Posttraumatic Stress Disorder, Depression, and Accelerated Aging: Leukocyte Telomere Length in the Nurses' Health Study II.Biological psychiatry global open science · 2023Article
- Left-sided heart failure burden and mortality in idiopathic pulmonary fibrosis: a population-based study.BMC pulmonary medicine · 2022Article
- Association of adipokines with frailty in heart failure.Acta bio-medica : Atenei Parmensis · 2021Article
- Prognostic significance of concentric left ventricular hypertrophy at peritoneal dialysis initiation.BMC nephrology · 2021Article
- Frailty in Acute and Chronic Coronary Syndrome Patients Entering Cardiac Rehabilitation.Journal of clinical medicine · 2021Review
- Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases.Oxidative medicine and cellular longevity · 2020Review
- Association of Age With Short-term and Long-term Mortality Among Patients Discharged From Intensive Care Units in France.JAMA network open · 2019Observational
- Exploratory Study of Andropause Syndrome in 40-65 Years in Arak: A Cross Sectional Study.Journal of family & reproductive health · 2018Article
- Age Does Not Affect Metoprolol's Effect on Perioperative Outcomes (From the POISE Database).Anesthesia and analgesia · 2018Article
- Telomere attrition in heart failure: a flow-FISH longitudinal analysis of circulating monocytes.Journal of translational medicine · 2018Article
- Telomere Length, Oxidative Stress, Inflammation and BDNF Levels in Siblings of Patients with Bipolar Disorder: Implications for Accelerated Cellular Aging.The international journal of neuropsychopharmacology · 2017Article
- Posttraumatic stress disorder and accelerated aging: PTSD and leukocyte telomere length in a sample of civilian women.Depression and anxiety · 2017Article
- Acute exercise activates p38 MAPK and increases the expression of telomere-protective genes in cardiac muscle.Experimental physiology · 2017Article
- Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs.Cellular signalling · 2016Article
- Cellular apoptosis in the cardiorenal axis.Heart failure reviews · 2016Review
- Assessment and impact of diastolic function by echocardiography in elderly patients.Journal of geriatric cardiology : JGC · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During normal aging, the heart undergoes functional, morphological and cellular changes. Although aging per se does not lead to the expression of heart failure, it is likely that age-associated changes lower the threshold for the manifestation of signs and symptoms of heart failure. In patients, the susceptibility, age of onset and pace of progression of heart failure are highly variable. The presence of conventional risk factors cannot completely explain this variability. Accumulation of DNA damage and telomere attrition results in an increase in cellular senescence and apoptosis, resulting in a decrease in the number and function of cells, contributing to the overall tissue and organ dysfunction. Biological aging, characterized by reduced telomere length, provides an explanation for the highly interindividual variable threshold to express the clinical syndrome of heart failure at some stage during life. In this review, we will elaborate on the current knowledge of aging of the heart, telomere biology and its potential role in the development of heart failure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.