ArticleDiabetologia2010
Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes.
Article in Diabetologia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 96 citations in OpenAlex.
- Review
- Discovery of placental microRNAs associated with maternal insulin sensitivity during pregnancy.Placenta · 2025Article
- Contribution of cytokeratin 19-expressing cells towards islet regeneration induced by multipotent stromal cell secreted proteins.Stem cells (Dayton, Ohio) · 2025Article
- Moderate beta-cell ablation triggers synergic compensatory mechanisms even in the absence of overt metabolic disruption.Communications biology · 2024Article
- Paracrine Signaling by Pancreatic Islet Cilia.Current opinion in endocrine and metabolic research · 2024Article
- β-Cell Heterogeneity and Plasticity.Advances in anatomy, embryology, and cell biology · 2024Review
- Beta-cell function in type 2 diabetes (T2DM): Can it be preserved or enhanced?Journal of diabetes · 2023Review
- Three-dimensional bioprinting of functional β-islet-like constructs.International journal of bioprinting · 2023Article
- Islet Dysfunction in a Novel Transgenic Model of T Cell Insulitis.Biomolecules · 2021Article
- Harnessing Proliferation for the Expansion of Stem Cell-Derived Pancreatic Cells: Advantages and Limitations.Frontiers in endocrinology · 2021Review
- Antidiabetic drug therapy alleviates type 1 diabetes in mice by promoting pancreatic α-cell transdifferentiation.Biochemical pharmacology · 2020Article
- Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- On the dynamics of the human endocrine pancreas and potential consequences for the development of type 1 diabetes.Acta diabetologica · 2020Review
- Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function.Frontiers in endocrinology · 2020Review
- Islet-immune interactions in type 1 diabetes: the nexus of beta cell destruction.Clinical and experimental immunology · 2019Review
- Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes.Current diabetes reports · 2019Review
- Glucagon Receptor Signaling and Glucagon Resistance.International journal of molecular sciences · 2019Review
- Pancreatic alpha-cell mass in the early-onset and advanced stage of a mouse model of experimental autoimmune diabetes.Scientific reports · 2019Article
- How, When, and Where Do Human β-Cells Regenerate?Current diabetes reports · 2019Review
- The challenge of modulating β-cell autoimmunity in type 1 diabetes.The lancet. Diabetes & endocrinology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisIn adults, the rate of beta cell replication is normally very low, but recent evidence suggests that it may increase during insulitis. We therefore studied tissue from donors with recent-onset type 1 diabetes to establish whether islet cell proliferation is increased during the disease process.
methodsParaffin-embedded pancreatic sections from ten donors with recent-onset type 1 diabetes and a range of relevant controls were stained by immunohistochemical techniques with antibodies against the proliferation markers Ki67 and minichromosome maintenance protein-2 (MCM-2). A combination staining technique involving immunoperoxidase and immunofluorescence methods was developed to quantify the numbers of alpha and beta cells with Ki67-positive nuclei and to investigate the relationship between insulitis and islet cell proliferation.
resultsIn non-diabetic control donors, only 1.1 +/- 0.3% (mean +/- SEM) of islets contained one or more Ki67(+) islet cells, whereas this proportion was increased markedly in recent-onset type 1 diabetes (10.88 +/- 2.5%; p < 0.005). An equivalent increase in Ki67(+) staining occurred in alpha and beta cells and was correlated positively with the presence of insulitis. A significant increase in the labelling of islet cells from type 1 diabetic donors was also seen when MCM-2 staining was employed. Increased islet cell proliferation was not evident in three donors with longer duration type 1 diabetes or in ten type 2 diabetic donors. CONCLUSIONS/
interpretationAlpha and beta cells undergo a marked increase in proliferation during the progression of type 1 diabetes in humans. The results imply that islet cell proliferation is re-initiated in response to the autoimmune attack associated with type 1 diabetes.
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