ArticleWorld journal of surgery2010
Clinicopathologic characteristics of colorectal cancer patients with synchronous and metachronous gastric cancer.
Article in World journal of surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 32 citations in OpenAlex.
- Metachronous gastro-oesophageal adenocarcinoma in a patient with colon adenocarcinoma.BMJ case reports · 2025Article
- Dual Primary Gastric and Rectal Adenocarcinoma: A Case Report with Management Insights : Dual Primary Gastric and Rectal Adenocarcinoma.Galen medical journal · 2025Article
- Incidence and pattern of second primary cancer in patients diagnosed with primary cancer.Oncology letters · 2024Article
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- Biomechanical Effectivity Evaluation of Single- and Double-Metal-Bar Methods with Rotation and Equilibrium Displacements in Nuss Procedure Simulations.Annals of biomedical engineering · 2024Article
- Dual primary gastric and colorectal cancer: A complex challenge in surgical oncology.World journal of gastrointestinal oncology · 2023Article
- Features of synchronous and metachronous dual primary gastric and colorectal cancer.World journal of gastrointestinal oncology · 2023Article
- Synchronous Gastric and Colon Cancer.Cureus · 2023Article
- Gastric tumorigenesis after radical resection combined with adjuvant chemotherapy for colorectal cancer: two case reports and a literature review.The Journal of international medical research · 2021Article
- Association between Mismatch-repair Genetic variation and the Risk of Multiple Primary Cancers: A Meta-Analysis.Journal of Cancer · 2017Article
- Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms.Gut and liver · 2016Article
- The value of preoperative screening colonoscopies in patients with biliary tract cancer.Journal of gastroenterology · 2016Article
- Prevalence and Risk Factors of Gastric Adenoma and Gastric Cancer in Colorectal Cancer Patients.Gastroenterology research and practice · 2016Article
- Multiple primary malignancies involving primary sporadic colorectal cancer in Japan: incidence of gastric cancer with colorectal cancer patients may be higher than previously recognized.World journal of surgical oncology · 2015Article
- Helicobacter pylori protein-specific antibodies and risk of colorectal cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Article
- The synchronous prevalence of colorectal neoplasms in patients with stomach cancer.Journal of the Korean Society of Coloproctology · 2011Article
- Clinicopathologic characteristics of colorectal cancer patients with synchronous and metachronous gastric cancer.World journal of surgery · 2011Article
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7 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated the characteristics of synchronous and metachronous gastric cancer in patients with colorectal cancer.
methodsWe reviewed 8,680 patients who underwent operations for primary sporadic colorectal cancer from 1989 to 2008. Synchronous gastric cancer was defined as gastric cancer diagnosed within 6 months of a colorectal cancer diagnosis. Gastric cancer diagnosed more than 6 months before or after colorectal cancer was defined as metachronous.
resultsThe incidences of synchronous and metachronous gastric cancer were 0.93 and 1.4%, respectively (combined 2.4%). The standardized incidence ratio was 1.199 (95% confidence interval [CI] = 1.005-1.420) when the patients with premetachronous gastric cancer were excluded. Patients with synchronous and metachronous gastric cancer were 5 years older on average compared to the control population without gastric cancer. In addition, multivariate analysis revealed an odds ratio (OR) of 3.6 for being male, OR = 2 for positive family history of solid tumors, OR = 2.2 for colonic lesion, and OR = 4 for MSH2 expression loss compared to patients without gastric cancer. Patients with postmetachronous gastric cancer (when compared to synchronous and premetachronous gastric cancer), a preoperative CEA level of less than 6 ng/ml, and a relatively early stage of colorectal cancer had significantly higher overall (p = 0.016, 0.007, and 0.004, respectively) and disease-free survival rates (p = 0.046, 0.003, and 0.004, respectively), only on univariate analysis. Lymphovascular invasion of colorectal cancer and an advanced stage of gastric cancer were independent poor prognostic factors for both overall (p = 0.018) and disease-free survival (p = 0.028).
conclusionsGastric cancer surveillance is recommended for patients with colorectal cancer, especially when the patient is old and male, has a positive family history of solid tumors, has a colonic lesion, or lacks MSH2 expression.
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