ArticleEcotoxicology (London, England)2010
Microcystin-LR synthesis as response to nitrogen: transcriptional analysis of the mcyD gene in Microcystis aeruginosa PCC7806.
Article in Ecotoxicology (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 77 citations in OpenAlex.
- Microplastic characteristics differentially influence cyanobacterial harmful algal bloom microbial community membership, growth, and toxin production.Sustainable microbiology · 2025Article
- Effects of allelochemical artemisinin in Artemisia annua on Microcystis aeruginosa: growth, death mode, and microcystin-LR changes.Environmental science and pollution research international · 2021Article
- Evaluating putative ecological drivers of microcystin spatiotemporal dynamics using metabarcoding and environmental data.Harmful algae · 2019Article
- Article
- Monitoring and research of microcystins and environmental factors in a typical artificial freshwater aquaculture pond.Environmental science and pollution research international · 2018Article
- Article
- Effects of microcystin-producing and microcystin-freeMicrocystis aeruginosa on enzyme activity and nutrient content in the rotifer Brachionus calyciflorus.Environmental science and pollution research international · 2017Article
- Influence of temperature, mixing, and addition of microcystin-LR on microcystin gene expression in Microcystis aeruginosa.MicrobiologyOpen · 2017Article
- Role of toxic and bioactive secondary metabolites in colonization and bloom formation by filamentous cyanobacteria Planktothrix.Harmful algae · 2016Review
- A review on factors affecting microcystins production by algae in aquatic environments.World journal of microbiology & biotechnology · 2016Review
- Microcystin Biosynthesis andBioMed research international · 2016Article
- Long-term monitoring reveals carbon-nitrogen metabolism key to microcystin production in eutrophic lakes.Frontiers in microbiology · 2015Article
- Microcystin mcyA and mcyE Gene Abundances Are Not Appropriate Indicators of Microcystin Concentrations in Lakes.PloS one · 2015Article
- Article
- Microcystin production and regulation under nutrient stress conditions in toxic microcystis strains.Applied and environmental microbiology · 2014Article
- Review
- Article
- Sucrose synthase in unicellular cyanobacteria and its relationship with salt and hypoxic stress.Planta · 2012Article
- Analyses of gene expression and physiological changes in Microcystis aeruginosa reveal the phytotoxicities of three environmental pollutants.Ecotoxicology (London, England) · 2012Article
- An active photosynthetic electron transfer chain required for mcyD transcription and microcystin synthesis in Microcystis aeruginosa PCC7806.Ecotoxicology (London, England) · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The influence of environmental factors on microcystin production by toxic cyanobacteria has been extensively studied. However, the effect of nitrogen on the synthesis of this toxin remains unclear because of the literature contradictory data. The aim of this work was to determine how nitrate affects the transcriptional response of mcyD gene and the microcystin-LR synthesis in Microcystis aeruginosa PCC 7806. For first time real time RT-PCR has been used to investigate the effect of nitrogen availability. Our results show that, under laboratory conditions, an excess of nitrate triggers Microcystis aeruginosa growth without increasing the synthesis of microcystin-LR per cell. The concentration of microcystin in the cultures correlates with mcyD gene expression, being both parameters independent of nitrate availability. Analysis of the bidirectional promoter mcy unravels that the transcription start points of mcyA and mcyD genes did not change under different nitrate regimes. The effect of nitrate inputs in the development of toxic blooms is primarily due to the increased growth rate and population, not to the induction of the mcy operon.
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