Evidence map›Paper›PMID 20532533›Full record

Trial reportInternational journal of colorectal disease2010

Endocytoscopic classification of preneoplastic lesions in the colorectum.

Gianluca Rotondano, Maria Antonia Bianco, Raffaele Salerno, Costantino Meucci, Antonio Prisco, Maria Lucia Garofano, Stefano Sansone, Livio Cipolletta

Registry-linked trialAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in International journal of colorectal disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02324374 (The Role of in Vivo Real Time Endocytoscopy in Diagnosing Colorectal Neoplasia), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02324374 nacompletednot on this mapstarted 2011, after this paper: background citation

The Role of in Vivo Real Time Endocytoscopy in Diagnosing Colorectal Neoplasia

TypeinterventionalSponsorUniversity of PennsylvaniaRan2011 to 2017Enrolled50ConditionsColon CancerArmsEndocystoscopy During Colonoscopy, Endocytoscope
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Image enhanced colonoscopy: updates and prospects-a review.Translational gastroenterology and hepatology · 2023
    Review
  3. Article
  4. Endocytoscopy: technology and clinical application in the lower GI tract.Translational gastroenterology and hepatology · 2020
    Review
  5. Article
  6. Article
  7. Article
  8. Ultra high magnification endoscopy: Is seeing really believing?World journal of gastrointestinal endoscopy · 2012
    Article
  9. New imaging techniques and opportunities in endoscopy.Nature reviews. Gastroenterology & hepatology · 2011
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gianluca RotondanoDivision of Gastroenterology and Digestive Endoscopy, Hospital A. Maresca, Torre del Greco, Italy. gianluca.rotondano@virgilio.it
Maria Antonia Bianco
Raffaele Salerno
Costantino Meucci
Antonio Prisco
Maria Lucia Garofano
Stefano Sansone
Livio Cipolletta

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study is to assess the capability of endocytoscopy (ECS) in differentiating neoplastic from nonneoplastic lesions in the colorectum and to validate an ECS classification.

methodsPatients with colorectal polypoid and nonpolypoid lesions < or =10 mm were prospectively included. ECS classification subgrouped nonneoplastic (EC 0) and neoplastic (EC 1-3) lesions. Lesions were observed at super-magnified view (450x) before endoscopic resection. Blinded pathological assessment was obtained.

resultsFifty-two lesions were examined in 49 patients (17 polypoid and 35 nonpolypoid). Final pathological diagnosis was normal mucosa or hyperplastic polyp in ten cases, low-grade adenoma in 29, high-grade adenoma in 11, and submucosal invasive cancer in two cases. Positive predictive values of each EC group were 100%, 93.1%, 90.1%, and 100%, respectively. ECS diagnosis correlated completely with pathology in the differentiation between neoplastic and nonneoplastic lesions.

conclusionsECS enabled observation of colorectal lesion at a subcellular level in vivo. The classification of ECS images had a good correlation with the final pathological diagnosis. ECS was useful to differentiate between neoplastic and nonneoplastic lesions.

Indexed as

AgedColonEndoscopyFemaleHumansMalePrecancerous ConditionsRectum

Identifiers

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.