ArticleNeuroradiology2011
Initial experience with the Penumbra Stroke System for recanalization of large vessel occlusions in acute ischemic stroke.
Article in Neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 47 citations in OpenAlex.
- Protected stent retriever thrombectomy prevents iatrogenic emboli in new vascular territories.Neuroradiology · 2015Trial
- Posterior Circulation Occlusions May Be Associated with Distal Emboli During Thrombectomy : Factors for Distal Embolization and a Review of the Literature.Clinical neuroradiology · 2019Review
- Dynamic protein expression of NF-κB following rat intracerebral hemorrhage and its association with apoptosis.Experimental and therapeutic medicine · 2018Article
- Computed tomography perfusion-based selection of endovascularly treated acute ischaemic stroke patients - Are there lessons to be learned from the pre-evidence era?The neuroradiology journal · 2017Article
- Mechanical Thrombectomy Using the New ERIC Retrieval Device Is Feasible, Efficient, and Safe in Acute Ischemic Stroke: A Swiss Stroke Center Experience.AJNR. American journal of neuroradiology · 2016Observational
- Endovascular therapy for ischemic stroke.Journal of clinical neurology (Seoul, Korea) · 2015Review
- Neurothrombectomy in the treatment of acute ischaemic stroke.Nature reviews. Neurology · 2013Review
- Factors influencing clinically meaningful recanalization after IV-rtPA in acute ischemic stroke.AJNR. American journal of neuroradiology · 2013Article
- A meta-analysis of observational intra-arterial stroke therapy studies using the Merci device, Penumbra system, and retrievable stents.AJNR. American journal of neuroradiology · 2013Article
- Initial experience with a self-expanding retrievable stent for recanalization of large vessel occlusions in acute ischemic stroke.Neuroradiology · 2012Article
- Computed Tomography Angiography in the Assessment of Patients With Stroke/TIA.The Neurohospitalist · 2011Article
- A systems approach towards intra-arterial management of acute ischemic stroke: need for novel outcome measures and a focus on sequence rather than steps.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2011Article
- How to make better use of thrombolytic therapy in acute ischemic stroke.Nature reviews. Neurology · 2011Review
- Recanalization and reperfusion in acute ischemic stroke.F1000 medicine reports · 2010Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe Penumbra system is a newly approved mechanical device for the treatment of acute stroke designed for better and faster recanalization. We describe our initial experience with the use of this device.
methodsWe studied 27 consecutive patients with acute ischemic strokes due to arterial occlusions presenting at our center from January to October 2009. The primary outcome was the degree of recanalization measured by thrombolysis in myocardial infarction (TIMI grade 2/3) at the end of the procedure. Secondary end points were the proportion of patients who achieved a modified Rankin scale (mRS) ≤2 at 3 months, all-cause mortality and intracerebral hemorrhage (ICH) on non contrast computed tomography at 24 h. Procedural complications were also recorded.
resultsOf 27 patients (13 male, mean age 61 years) in the study, 22 (81%) patients had anterior circulation strokes and five (18%) had posterior circulation strokes. Twenty-three (85%) patients achieved TIMI grade 2/3 recanalization at completion of the procedure. Excluding five patients who needed use of a second device, the Penumbra system achieved TIMI grade 2/3 recanalization in 67% of patients. Thirteen (48%) patients had mRS ≤2 at 3-month follow-up. Procedural and post-procedural complications included vasospasm (3.7%), distal emboli (48.1%), and ICH (33.3%). The distribution of ICH is as follows: hemorrhagic infarct type 1 (25.9%), parenchymal hemorrhage type 1 (3.7%), and parenchymal hemorrhage type 2 (3.7%). All-cause mortality was 19%.
conclusionsHigh recanalization rates and good clinical outcomes are achievable with the Penumbra system. Complication rates are comparable to a previously published literature.
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