ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2011
Serum insulin-like growth factor-I is a marker for assessing the severity of vertebral fractures in postmenopausal women with type 2 diabetes mellitus.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Impact of Time Since Diagnosis and Age on Fracture Risk in Young Adults With Type 1 and Type 2 Diabetes.The Kaohsiung journal of medical sciences · 2026Article
- Review
- Biochemical Markers of Bone Fragility in Patients with DiabetesThe Journal of clinical endocrinology and metabolism · 2023Article
- Type 2 diabetes and bone fragility in children and adults.World journal of diabetes · 2022Review
- The Potential Therapeutic Role of Metformin in Diabetic and Non-Diabetic Bone Impairment.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Fracture risk assessment in diabetes mellitus.Frontiers in endocrinology · 2022Review
- Sex-specific associations of serum insulin-like growth factor-1 with bone density and risk of fractures in Chinese patients with type 2 diabetes.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Which Is a Better Skeletal Muscle Mass Index for the Evaluation of Physical Abilities: The Present Height or Maximum Height?Internal medicine (Tokyo, Japan) · 2021Article
- Shockwave Therapy Modulates the Expression of BMP2 for Prevention of Bone and Cartilage Loss in the Lower Limbs of Postmenopausal Osteoporosis Rat Model.Biomedicines · 2020Article
- Obesity and Bone Health: A Complex Link.Frontiers in cell and developmental biology · 2020Review
- Pathophysiology and Management of Type 2 Diabetes Mellitus Bone Fragility.Journal of diabetes research · 2020Review
- Overweight and underweight are risk factors for vertebral fractures in patients with type 2 diabetes mellitus.Journal of bone and mineral metabolism · 2019Article
- Diabetes Mellitus-induced Bone Fragility.Internal medicine (Tokyo, Japan) · 2018Article
- Assessment of bone quality in patients with diabetes mellitus.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Review
- 1α,25-Dihydroxyvitamin DThe Journal of biological chemistry · 2017Article
- Biomarkers in Sports and Exercise: Tracking Health, Performance, and Recovery in Athletes.Journal of strength and conditioning research · 2017Review
- Decreased Serum Insulin-like Growth Factor-I is a Risk Factor for Non-vertebral Fractures in Diabetic Postmenopausal Women.Internal medicine (Tokyo, Japan) · 2017Article
- Assessment of bone turnover and bone quality in type 2 diabetic bone disease: current concepts and future directions.Bone research · 2016Review
- Mechanisms involved in altered bone metabolism in diabetes: a narrative review.Journal of diabetes and metabolic disorders · 2016Review
- Bone cells and bone turnover in diabetes mellitus.Current osteoporosis reports · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledAlthough previous studies indicated that serum insulin-like growth factor-I (IGF-I) was inversely associated with the presence of vertebral fractures (VFs), little is known whether serum IGF-I is associated with multiple VFs. We report that serum IGF-I could be clinically useful for assessing the severity of VFs in type 2 diabetic postmenopausal women.
introductionThe number of VFs is associated with the mobility and mortality of the elderly people. Although serum IGF-I is inversely associated with the presence of VFs, little is known about the relationship between serum IGF-I and multiple VFs.
methodsIn this cross-sectional study, we recruited 479 men and 334 postmenopausal women with type 2 diabetes mellitus and measured serum IGF-I, bone mineral density, and bone turnover markers. Lateral X-ray films of the thoracic and lumbar spine were taken to diagnose the VF.
resultsIn postmenopausal women, serum IGF-I level was decreased when the number of VFs was increased [no VFs; 138 ± 51 ng/ml (mean ± SD) vs. one VF; 119 ± 42 (p = 0.006), two VFs; 103 ± 39 (p = 0.002), and three and more VFs; 91 ± 40 (p < 0.001)]. Multiple logistic regression analysis adjusted for age, duration of diabetes, body mass index, serum creatinine, and HbA(1c) showed that serum IGF-I level was inversely associated with the presence of one VF [odds ratio (OR) = 0.67, p = 0.029], two VFs (OR = 0.40, p = 0.017), as well as three and more VFs (OR = 0.27, p = 0.005). These associations were still significant after the additional adjustment for BMD at the lumbar spine. In contrast, no significant association of serum IGF-I level with VFs was found in men.
conclusionsSerum IGF-I level was inversely associated with the number of prevalent VFs in postmenopausal women with type 2 diabetes, suggesting that serum IGF-I could be clinically useful for assessing the severity of VFs in the population.
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