ArticlePloS one2010
Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Inhaled Nitric Oxide Promotes Angiogenesis in the Rodent Developing Brain.International journal of molecular sciences · 2023Article
- Association between short-term air pollution exposure and traumatic intracranial hemorrhage: pilot evidence from Taiwan.Frontiers in neurology · 2023Article
- Article
- Neuroprotective role of nitric oxide inhalation and nitrite in a Neonatal Rat Model of Hypoxic-Ischemic Injury.PloS one · 2022Article
- Nitric oxide and the brain. Part 1: Mechanisms of regulation, transport and effects on the developing brain.Pediatric research · 2021Review
- Nitric oxide and the brain. Part 2: Effects following neonatal brain injury-friend or foe?Pediatric research · 2021Review
- Modulation of Microglial Activation by Adenosine A2a Receptor in Animal Models of Perinatal Brain Injury.Frontiers in neurology · 2018Article
- Intracarotid Sodium Nitroprusside on Fifth Post Ischemic Stroke Day in Middle Cerebral Artery Occlusion Rat Model.Journal of clinical and diagnostic research : JCDR · 2017Article
- Pharmacological approaches to intervention in hypomyelinating and demyelinating white matter pathology.Neuropharmacology · 2016Review
- Impact of inhaled nitric oxide on the sulfatide profile of neonatal rat brain studied by TOF-SIMS imaging.International journal of molecular sciences · 2014Article
- Inhaled nitric oxide protects males but not females from neonatal mouse hypoxia-ischemia brain injury.Translational stroke research · 2013Article
- Antenatal insults modify newborn olfactory function by nitric oxide produced from neuronal nitric oxide synthase.Experimental neurology · 2012Article
- Neuroanatomical, sensorimotor and cognitive deficits in adult rats with white matter injury following prenatal ischemia.Brain pathology (Zurich, Switzerland) · 2012Article
- Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale.Medical hypotheses · 2011Article
- Nitric oxide counteracts the hyperoxia-induced proliferation and proinflammatory responses of mouse astrocytes.Free radical biology & medicine · 2011Article
- Learning to live with patency of the ductus arteriosus in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2011Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInhaled nitric oxide (iNO) is one of the most promising therapies used in neonates. However, little information is known about its impact on the developing brain submitted to excitotoxic challenge. METHODOLOGY/PRINCIPAL
findingsWe investigated here the effect of iNO in a neonatal model of excitotoxic brain lesions. Rat pups and their dams were placed in a chamber containing 20 ppm NO during the first week of life. At postnatal day (P)5, rat pups were submitted to intracranial injection of glutamate agonists. At P10, rat pups exposed to iNO exhibited a significant decrease of lesion size in both the white matter and cortical plate compared to controls. Microglia activation and astrogliosis were found significantly decreased in NO-exposed animals. This neuroprotective effect was associated with a significant decrease of several glutamate receptor subunits expression at P5. iNO was associated with an early (P1) downregulation of pCREB/pAkt expression and induced an increase in pAkt protein concentration in response to excitotoxic challenge (P7).
conclusionThis study is the first describe and investigate the neuroprotective effect of iNO in neonatal excitotoxic-induced brain damage. This effect may be mediated through CREB pathway and subsequent modulation of glutamate receptor subunits expression.
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