ArticlePLoS genetics2010
14-3-3 mediates histone cross-talk during transcription elongation in Drosophila.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 54 citations in OpenAlex.
- DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5.Nucleic acids research · 2024Article
- Different Protein Groups Involved in Transcription Regulation in Development and Housekeeping Genes in Drosophila.Doklady. Biochemistry and biophysics · 2023Article
- R132H IDH1 sensitizes glioma to the antiproliferative and cytotoxic effects of BET inhibition.Journal of cancer research and clinical oncology · 2022Article
- Tctp regulates the level and localization of Foxo for cell growth in Drosophila.Cell death discovery · 2022Article
- Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions.Biochemical Society transactions · 2021Review
- Inhibition of Notch signaling by the p105 and p180 subunits ofJournal of cell science · 2019Article
- Elongator complex is required for long-term olfactory memory formation inLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Mitogen- and stress-activated protein kinase 1 is required for gonadotropin-releasing hormone-mediated activation of gonadotropin α-subunit expression.The Journal of biological chemistry · 2017Article
- High-throughput screening of a GlaxoSmithKline protein kinase inhibitor set identifies an inhibitor of human cytomegalovirus replication that prevents CREB and histone H3 post-translational modification.The Journal of general virology · 2017Article
- Stepping inside the realm of epigenetic modifiers.Biomolecular concepts · 2015Review
- Control of histone H3 phosphorylation by CaMKIIδ in response to haemodynamic cardiac stress.The Journal of pathology · 2015Article
- Sensing core histone phosphorylation - a matter of perfect timing.Biochimica et biophysica acta · 2014Review
- Genome-wide analysis of regulation of gene expression and H3K9me2 distribution by JIL-1 kinase mediated histone H3S10 phosphorylation in Drosophila.Nucleic acids research · 2014Article
- Single nucleotide polymorphisms for feed efficiency and performance in crossbred beef cattle.BMC genetics · 2014Article
- Distinct isoforms of the Drosophila Brd4 homologue are present at enhancers, promoters and insulator sites.Nucleic acids research · 2013Article
- Evidence against a role for the JIL-1 kinase in H3S28 phosphorylation and 14-3-3 recruitment to active genes in Drosophila.PloS one · 2013Article
- Synchronous recruitment of epigenetic modifiers to endotoxin synergistically activated Tnf-α gene in acute kidney injury.PloS one · 2013Article
- Histone regulation in the CNS: basic principles of epigenetic plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Review
- Histone H3 phosphorylation - a versatile chromatin modification for different occasions.Biochimie · 2012Review
- Genome-wide phosphoacetylation of histone H3 at Drosophila enhancers and promoters.Genome research · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-translational modifications of histone proteins modulate the binding of transcription regulators to chromatin. Studies in Drosophila have shown that the phosphorylation of histone H3 at Ser10 (H3S10ph) by JIL-1 is required specifically during early transcription elongation. 14-3-3 proteins bind H3 only when phosphorylated, providing mechanistic insights into the role of H3S10ph in transcription. Findings presented here show that 14-3-3 functions downstream of H3S10ph during transcription elongation. 14-3-3 proteins localize to active genes in a JIL-1-dependent manner. In the absence of 14-3-3, levels of actively elongating RNA polymerase II are severely diminished. 14-3-3 proteins interact with Elongator protein 3 (Elp3), an acetyltransferase that functions during transcription elongation. JIL-1 and 14-3-3 are required for Elp3 binding to chromatin, and in the absence of either protein, levels of H3K9 acetylation are significantly reduced. These results suggest that 14-3-3 proteins mediate cross-talk between histone phosphorylation and acetylation at a critical step in transcription elongation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.