ArticlePloS one2010
Atoh8, a bHLH transcription factor, is required for the development of retina and skeletal muscle in zebrafish.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Role of ATOH8 in Mitigating Cardiac Fibrosis in Heart Failure via Inhibition of the Transcriptional Repression of Smad7 by RUNX2.Biomolecules & therapeutics · 2026Article
- Network-based discovery of regulatory drivers of cognitive decline in alzheimer's disease.npj aging · 2026Article
- Identification of differentially expressed lncRNAs in different daily weight gains of Jiangquan black pigs and functional analysis of LOC100518120.BMC genomics · 2026Article
- ATOH8 is crucial for the differentiation of human trophoblast stem cells into extravillous trophoblasts.Scientific reports · 2025Article
- atoh8 expression pattern in early zebrafish embryonic development.Histochemistry and cell biology · 2021Article
- In focus in HCB.Histochemistry and cell biology · 2021Article
- Targeted deletion of Atoh8 results in severe hearing loss in mice.Genesis (New York, N.Y. : 2000) · 2021Article
- BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts.Bone research · 2020Article
- The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.Science signaling · 2019Article
- Murine transcription factor Math6 is a regulator of placenta development.Scientific reports · 2018Article
- Article
- Downregulation of ATOH8 induced by EBV-encoded LMP1 contributes to the malignant phenotype of nasopharyngeal carcinoma.Oncotarget · 2016Article
- Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8).PloS one · 2016Article
- A novel interaction between ATOH8 and PPP3CB.Histochemistry and cell biology · 2016Article
- The Role of Atonal Factors in Mechanosensory Cell Specification and Function.Molecular neurobiology · 2015Article
- The role of Hath6, a newly identified shear-stress-responsive transcription factor, in endothelial cell differentiation and function.Journal of cell science · 2014Article
- ATOH8, a regulator of skeletal myogenesis in the hypaxial myotome of the trunk.Histochemistry and cell biology · 2014Article
- The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels.British journal of haematology · 2014Article
- The transcription factor Atonal homolog 8 regulates Gata4 and Friend of Gata-2 during vertebrate development.The Journal of biological chemistry · 2013Article
- Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish.BMC biology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMath6/atoh8, a bHLH transcription factor, is thought to be indispensable for early embryonic development and likely has important roles in vertebrate tissue-specific differentiation. However, the function of Atoh8 during early development is not clear because homozygous knockout causes embryonic lethality in mice. We have examined the effects of the atoh8 gene on the differentiation of retina and skeletal muscle during early development in zebrafish.
resultsWe isolated a Math6 homologue in zebrafish, designated as zebrafish atoh8. Whole -mount in situ hybridization analysis showed that zebrafish atoh8 is dynamically expressed mainly in developing retina and skeletal muscle. Atoh8-MO knock-down resulted in reduced eye size with disorganization of retinal lamination. The reduction of atoh8 function also affected the arrangement of paraxial cells and differentiated muscle fibers during somite morphogenesis.
conclusionOur results show that Atoh8 is an important regulator for the development of both the retina and skeletal muscles necessary for neural retinal cell and myogenic differentiation during zebrafish embryogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.