ReviewDeutsches Arzteblatt international2010
The surgical treatment of hepatic metastases in colorectal carcinoma.
Review in Deutsches Arzteblatt international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Analysis of metabolic liver function and MR-morphological cholestatic parameters after SBRT of liver metastases.Radiation oncology (London, England) · 2025Article
- Gut microbiota dysbiosis impairs TGF-β/Smad4 signaling to drive postoperative metastasis in colorectal cancer.Frontiers in microbiology · 2025Article
- Combined Resection of Liver and Hilar Bifurcation for Colorectal Liver Metastasis: A Single-Center Experience and Review of the Literature.Visceral medicine · 2024Article
- Robotic Stereotactic Body Radiation Therapy for Oligometastatic Liver Metastases: A Systematic Review of the Literature and Evidence Quality Assessment.Diagnostics (Basel, Switzerland) · 2024Review
- Article
- Iron Oxide Nanoparticle-Based Hyperthermia as a Treatment Option in Various Gastrointestinal Malignancies.Nanomaterials (Basel, Switzerland) · 2021Review
- Survey on Liver Tumour Resection Planning System: Steps, Techniques, and Parameters.Journal of digital imaging · 2020Review
- Two-Stage Hepatectomy and ALPPS for Advanced Bilateral Liver Metastases: a Tailored Approach Balancing Risk and Outcome.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019Article
- Circulating Levels of Osteopontin Predict Patients' Outcome after Resection of Colorectal Liver Metastases.Journal of clinical medicine · 2018Article
- Synchronous colorectal liver metastases: focus on the elderly : An Effectiveness Study from Routine Care.Langenbeck's archives of surgery · 2017Article
- Clinical results of mean GTV dose optimized robotic guided SBRT for liver metastases.Radiation oncology (London, England) · 2016Article
- The Influence of Liver Resection on Intrahepatic Tumor Growth.Journal of visualized experiments : JoVE · 2016Article
- [Preoperative imaging/operation planning for liver surgery].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2015Review
- The clinical relevance of the Fong and the Nordlinger scores in the era of effective neoadjuvant chemotherapy for colorectal liver metastasis.Surgery today · 2015Article
- Treatment strategies for colorectal carcinoma with synchronous liver metastases: Which way to go?World journal of gastroenterology · 2015Review
- [Morbidity, mortality and analysis of prognostic factors for colorectal cancer].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2015Article
- The evolution of cancer surgery and future perspectives.Nature reviews. Clinical oncology · 2015Review
- Role of stereotactic body radiotherapy for oligometastasis from colorectal cancer.World journal of gastroenterology · 2014Review
- Prognostic importance of some clinical and therapeutic factors for the effect of portal vein embolization in patients with primarily inoperable colorectal liver metastases.Archives of medical science : AMS · 2013Article
- Surgical intervention for pulmonary metastases.Deutsches Arzteblatt international · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal carcinoma with hepatic metastases was long considered an incurable disease. Recent advances in surgical treatment have substantially improved the affected patients' prognosis. At first, surgery was only performed in patients whose hepatic tumor burden was small (<4 nodes, <5 cm). Currently, however, the main issue is the feasibility of curative resection of all metastases.
methodThe PubMed literature database was selectively searched for articles with the keywords "colorectal liver metastases," "chemotherapy," and "surgery." Particular attention was devoted to studies of large groups of patients, randomized trials, the German guidelines, and an analysis of the authors' own patient population.
resultsOnly 10% to 20% of all patients are candidates for surgical therapy (hepatic resection), as the rest are disqualified either by extensive liver involvement or by extrahepatic neoplasia. A further 10% of patients have hepatic metastases that are primarily considered inoperable, yet later become amenable to surgery after interdisciplinary treatment involving preoperative chemotherapy, portal-vein embolization, two-stage hepatectomy, and/or locally ablative procedures. Chemotherapy is probably beneficial after hepatic resection, although the benefit has not yet been definitively demonstrated by clinical trials. Therefore, chemotherapy should only be given perioperatively in selected cases, when recommended by an interdisciplinary treatment team.
conclusionA multimodal approach to the treatment of hepatic metastases of colorectal carcinoma has led to an increase in the number of resections and to an improved long-term survival rate (currently more than 40% at 5 years).
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