ArticlePloS one2010
Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Anti-GPI scFv as a Promising Tool for Intervention Against Cerebral Malaria in Mice.International journal of molecular sciences · 2026Article
- Characterization of experimental cerebral malaria by volumetric MRI A comparative study across the sexes.PloS one · 2025Article
- Contribution of Magnetic Resonance Imaging Studies to the Understanding of Cerebral Malaria Pathogenesis.Pathogens (Basel, Switzerland) · 2024Review
- Pathogenetic mechanisms and treatment targets in cerebral malaria.Nature reviews. Neurology · 2023Review
- Genetic mapping of determinants in drug resistance, virulence, disease susceptibility, and interaction of host-rodent malaria parasites.Parasitology international · 2022Review
- Review
- Article
- Effect of Brugia pahangi co-infection with Plasmodium berghei ANKA in gerbils (Meriones unguiculatus).Parasitology research · 2020Article
- Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Host genetics in malaria: lessons from mouse studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.JCI insight · 2018Article
- Pathogenesis of Plasmodium berghei ANKA infection in the gerbil (Meriones unguiculatus) as an experimental model for severe malaria.Parasite (Paris, France) · 2017Article
- Mouse ENU Mutagenesis to Understand Immunity to Infection: Methods, Selected Examples, and Perspectives.Genes · 2014Review
- Article
- Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9.Malaria journal · 2013Article
- In silico QTL mapping of maternal nurturing ability with the mouse diversity panel.Physiological genomics · 2012Article
- Haplotype Association Mapping Identifies a Candidate Gene Region in Mice Infected With Staphylococcus aureus.G3 (Bethesda, Md.) · 2012Article
- Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type.Genes and immunity · 2012Article
- Forward genetic approaches to understanding complex behaviors.Current topics in behavioral neurosciences · 2012Review
- The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria.PPAR research · 2012Article
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Authors and funding
13 authors.
Funding
Abstract
The genetic background of a patient determines in part if a person develops a mild form of malaria and recovers, or develops a severe form and dies. We have used a mouse model to detect genes involved in the resistance or susceptibility to Plasmodium berghei malaria infection. To this end we first characterized 32 different mouse strains infected with P. berghei and identified survival as the best trait to discriminate between the strains. We found a locus on chromosome 6 by linking the survival phenotypes of the mouse strains to their genetic variations using genome wide analyses such as haplotype associated mapping and the efficient mixed-model for association. This new locus involved in malaria resistance contains only two genes and confirms the importance of Ppar-gamma in malaria infection.
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