ArticleKidney international2010
Associations of estradiol and testosterone with serum phosphorus in older men: the Osteoporotic Fractures in Men study.
Article in Kidney international, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Short-Term Changes in Bone Metabolism Among Transgender Men Starting Gender-Affirming Hormone Therapy: A Systematic Review and Meta-analysis.Calcified tissue international · 2024Pooled it
- Reduction of calprotectin and phosphate during testosterone therapy in aging men: a randomized controlled trial.Journal of endocrinological investigation · 2017Trial
- Update on testosterone deficiency and therapeutic options for testosterone replacement therapy.Nature reviews. Urology · 2026Review
- Positive association between standing height and bone mineral density in adolescents aged 12-19: NHANES 2011-2018 : Author.BMC pediatrics · 2025Article
- Characterisation of phosphate transport in epididymis and prostate with possible relevance for semen quality.EBioMedicine · 2025Article
- Serum Phosphate in the General Population: A Need for Sex-Specific Reference Intervals.The Journal of clinical endocrinology and metabolism · 2025Article
- The role of age and sex in non-linear dilution adjustment of spot urine arsenic.BMC nephrology · 2024Article
- Phosphate in Cardiovascular Disease: From New Insights Into Molecular Mechanisms to Clinical Implications.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Sexual dimorphisms in serum calcium and phosphate concentrations in the Rotterdam Study.Scientific reports · 2023Article
- Serum Analytes of American Mink (Neovison Vison) Challenged with Aleutian Mink Disease Virus.Animals : an open access journal from MDPI · 2022Article
- Serum Phosphate, BMI, and Body Composition of Middle-Aged and Older Adults: A Cross-Sectional Association Analysis and Bidirectional Mendelian Randomization Study.The Journal of nutrition · 2022Observational
- Estrogen and estrogen receptors in kidney diseases.Renal failure · 2021Review
- Environment-wide association study to comprehensively test and validate associations between nutrition and lifestyle factors and testosterone deficiency: NHANES 1988-1994 and 1999-2004.Hormones (Athens, Greece) · 2020Article
- Yield of diagnostic tests in unexplained renal hypophosphatemia: a case series.BMC nephrology · 2018Article
- Serum phosphate levels are related to all-cause, cardiovascular and COPD mortality in men.European journal of epidemiology · 2018Article
- Serum Phosphate Is Associated With Fracture Risk: The Rotterdam Study and MrOS.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Phosphorus as predictive factor for erectile dysfunction in middle aged men: A cross sectional study in Korea.Investigative and clinical urology · 2016Article
- Relationship of dietary phosphate intake with risk of end-stage renal disease and mortality in chronic kidney disease stages 3-5: The Modification of Diet in Renal Disease Study.Kidney international · 2016Article
- Sex steroid actions in male bone.Endocrine reviews · 2014Review
- Association of serum inorganic phosphate with sex steroid hormones and vitamin D in a nationally representative sample of men.Andrology · 2014Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
Abstract
Postmenopausal women consistently have higher phosphorus levels than similarly aged men. As it is known that estradiol induces phosphaturia in rodents, we evaluated the cross-sectional association of sex hormones with serum phosphorus in 1346 community-living older men (mean age 76) of which 18% had moderate (stage 3) kidney disease. Using linear regression with serum phosphorus levels as the dependent variable, we found that for each 10 pg/ml higher total estradiol level there was a statistically significant 0.05 mg/dl lower serum phosphorus when adjusted for age, ethnicity, testosterone, sex hormone-binding globulin, calcium, estimated glomerular filtration rate, intact parathyroid hormone, 25(OH) vitamin D, bone mineral density, and alkaline phosphatase. These results were similar in individuals with or without chronic kidney disease. Serum testosterone concentrations were also statistically significantly associated with lower serum phosphorus levels. We confirmed these results in an independent sample of 2555 older men, wherein these associations were not attenuated when adjusted for fibroblast growth factor-23 levels. Hence, our study of community-living older men suggests that estradiol may directly or indirectly induce phosphaturia in humans. The mechanism responsible for the association of testosterone with serum phosphorus remains to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.