ReviewNature reviews. Neurology2010
Restless legs syndrome: pathophysiology, clinical presentation and management.
Review in Nature reviews. Neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 8 syntheses or guidelines pooled it, 303 citations in OpenAlex.
- Migraine and Restless Legs Syndrome: A Meta-Analysis.Journal of sleep research · 2026Pooled it
- Polysomnographic features of idiopathic restless legs syndrome: a systematic review and meta-analysis of 13 sleep parameters and 23 leg movement parameters.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Pooled it
- Clinical Efficacy and Safety of Massage for the Treatment of Restless Leg Syndrome in Hemodialysis Patients: A Meta-Analysis of 5 Randomized Controlled Trials.Frontiers in psychiatry · 2022Pooled it
- [Frequent neurological diseases associated with the restless legs syndrome].Der Nervenarzt · 2018Pooled it
- Pooled it
- Prevalence of restless legs syndrome in North American and Western European populations: a systematic review.Sleep medicine · 2011Pooled it
- Dopamine agonists for restless legs syndrome.The Cochrane database of systematic reviews · 2011Pooled it
- Levodopa for restless legs syndrome.The Cochrane database of systematic reviews · 2011Pooled it
- Transdermal rotigotine for the perioperative management of restless legs syndrome.BMC neurology · 2012Trial
- Migraine and restless legs syndrome in women.Cephalalgia : an international journal of headache · 2012Trial
- Investigation of the "Not Better Explained" Diagnosis Criteria in Sleep Disorder Classifications: A Systematic Content Analysis and Critical Review.Journal of sleep research · 2026Review
- Comparative Peripheral Blood Transcriptomic Profiles in Parkinson's Disease and Restless Legs Syndrome: An Exploratory Between-Cohort Analysis.International journal of molecular sciences · 2026Article
- Restless Legs Syndrome: A Network Model of Iron-Dependent Neuromodulation-A Narrative Review.Brain sciences · 2026Review
- The Effects of Tyrosine Hydroxylase Blockade in Mice Lacking the Norepinephrine Transporter (NET-KO Mice).International journal of molecular sciences · 2026Article
- Vitamin D and Sleep Disorders.Advances in experimental medicine and biology · 2026Review
- Effects of herbal medicines containing Paeoniae Radix on patients with restless legs syndrome: A retrospective chart review study.World journal of clinical cases · 2025Article
- Restless Legs Syndrome in Adult Primary Care.Cureus · 2025Review
- RLS shows increased resting state sympathetic activity and decreased sympathetic response capability.Journal of neurology · 2025Article
- Association of restless legs syndrome and obesity: A sub-population of the MASHAD cohort study.Neurobiology of sleep and circadian rhythms · 2025Article
- Alterations in hippocampal somatostatin interneurons, GABAergic metabolism, and ASL perfusion in an aged male mouse model of POCD aggravated by sleep fragmentation.Physiological reports · 2024Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Restless legs syndrome (RLS) is a somatosensory network disorder that is clinically diagnosed according to four main criteria: an urge to move the legs, usually associated with unpleasant leg sensations; induction or exacerbation of symptoms by rest; symptom relief on activity; and diurnal fluctuations in symptoms with worsening in the evening and at night. Genetic variants in four chromosomal regions have been identified that increase the risk of RLS. In addition, various different lesions, ranging from peripheral neuropathies to spinal cord lesions or alterations of brain metabolism, are implicated in RLS. In most cases, sleep disorders with frequent sleep fragmentation and characteristic periodic limb movements during sleep can be identified during a polysomnographic recording. The first-line drugs for RLS are dopaminergic agents, which are effective in low to moderate doses. Alternative or additional treatments include opioids and anticonvulsants. Augmentation-paradoxical worsening of symptoms by dopaminergic treatment-is the main problem encountered in difficult-to-treat patients. Iron deficiency must be identified and treated by supplementation, both to improve RLS symptoms and to potentially lower the risk of augmentation. Here, we review the latest studies pertaining to the pathophysiology, clinical presentation and management of RLS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.