ReviewAsian journal of andrology2010
Obesity: modern man's fertility nemesis.
Review in Asian journal of andrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 5 syntheses or guidelines pooled it, 186 citations in OpenAlex.
- The impact of bariatric surgery on male sexual function: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- The global prevalence of sexual dysfunction in obese and overweight women: a systematic review and meta-analysis.BMC women's health · 2023Pooled it
- Impact of Physical Activity and Sedentary Behavior on Spontaneous Female and Male Fertility: A Systematic Review.Journal of physical activity & health · 2023Pooled it
- Impact of Bariatric Surgery on Male Sex Hormones and Sperm Quality: a Systematic Review and Meta-Analysis.Obesity surgery · 2019Pooled it
- Follicle-stimulating hormone as a predictor for sperm retrieval rate in patients with nonobstructive azoospermia: a systematic review and meta-analysis.Asian journal of andrologyPooled it
- The effect of bariatric surgery on patient HRQOL and sexual health during a 1-year postoperative period.Obesity surgery · 2015Trial
- It is not what you weigh, it is how you present it: body size, attractiveness, physical functioning, and access to partnership and sexuality for older men and women.Social forces; a scientific medium of social study and interpretation · 2025Article
- Unmasking the Epigenome: Insights into Testicular Cell Dynamics and Reproductive Function.International journal of molecular sciences · 2025Review
- High-Fat Diets Disturb Rat Epididymal Sperm Maturation.International journal of molecular sciences · 2025Article
- The Impact of Parental Preconception Nutrition, Body Weight, and Exercise Habits on Offspring Health Outcomes: A Narrative Review.Nutrients · 2024Review
- Article
- Decoding the Epigenetics of Infertility: Mechanisms, Environmental Influences, and Therapeutic Strategies.Epigenomes · 2024Review
- Article
- Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist.Journal of endocrinological investigation · 2024Review
- Potential impact of GLP-1 receptor agonists on male fertility: a fable of caution.Frontiers in physiology · 2024Article
- Serum lipid profile levels and semen quality: new insights and clinical perspectives for male infertility and men's health.International urology and nephrology · 2023Article
- Switching from high-fat diet to normal diet ameliorate BTB integrity and improve fertility potential in obese male mice.Scientific reports · 2023Article
- How much obesity and diabetes do impair male fertility?Reproductive biology and endocrinology : RB&E · 2023Article
- How far will they go? Distance and driving times that north American men travel to see a reproductive urologist.Andrologia · 2022Article
- Sperm Dysfunction in the Testes and Epididymides due to Overweight and Obesity Is Not Caused by Oxidative Stress.International journal of endocrinology · 2022Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The obesity pandemic has grown to concerning proportions in recent years, not only in the Western World, but in developing countries as well. The corresponding decrease in male fertility and fecundity may be explained in parallel to obesity, and obesity should be considered as an etiology of male fertility. Studies show that obesity contributes to infertility by reducing semen quality, changing sperm proteomes, contributing to erectile dysfunction, and inducing other physical problems related to obesity. Mechanisms for explaining the effect of obesity on male infertility include abnormal reproductive hormone levels, an increased release of adipose-derived hormones and adipokines associated with obesity, and other physical problems including sleep apnea and increased scrotal temperatures. Recently, genetic factors and markers for an obesity-related infertility have been discovered and may explain the difference between fertile obese and infertile obese men. Treatments are available for not only infertility related to obesity, but also as a treatment for the other comorbidities arising from obesity. Natural weight loss, as well as bariatric surgery are options for obese patients and have shown promising results in restoring fertility and normal hormonal profiles. Therapeutic interventions including aromatase inhibitors, exogenous testosterone replacement therapy and maintenance and regulation of adipose-derived hormones, particularly leptin, may also be able to restore fertility in obese males. Because of the relative unawareness and lack of research in this area, controlled studies should be undertaken and more focus should be given to obesity as an etiolgy of male infertility.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.