ArticleMenopause (New York, N.Y.)
TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women.
Article in Menopause (New York, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Polymorphisms in the RANK/RANKL genes and their effect on bone specific prognosis in breast cancer patients.BioMed research international · 2014Trial
- Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis.Science (New York, N.Y.) · 2026Article
- Genetic determinants of age at menarche: does the LIN28B gene play a role? A narrative review.Hormones (Athens, Greece) · 2025Review
- Strong evidence supports the use of estradiol therapy for the treatment of vaginal inflammation: a two-way Mendelian randomization study.European journal of medical research · 2024Article
- Puberty classifications in beef heifers are moderately to highly heritable and associated with candidate genes related to cyclicity and timing of puberty.Frontiers in genetics · 2024Article
- RANKL Is Independently Associated with Increased Risks of Non-Alcoholic Fatty Liver Disease in Chinese Women with PCOS: A Cross-Sectional Study.Journal of clinical medicine · 2023Article
- Women's reproductive span: a systematic scoping review.Human reproduction open · 2022Article
- Genetic Mutations inFrontiers in medicine · 2021Article
- Investigation of The Relationship ofBalkan journal of medical genetics : BJMG · 2020Article
- Polymorphisms within the RANK and RANKL Encoding Genes in Patients with Rheumatoid Arthritis: Association with Disease Progression and Effectiveness of the Biological Treatment.Archivum immunologiae et therapiae experimentalis · 2020Article
- Genetics of pubertal timing.Current opinion in pediatrics · 2018Review
- Gene polymorphisms in RANKL/RANK/OPG pathway are associated with ages at menarche and natural menopause in Chinese women.BMC women's health · 2015Article
- Article
- A chromosome 19 locus positively influences the number of retrieved oocytes during stimulated cycles in Brazilian women.Journal of assisted reproduction and genetics · 2012Article
- Association analyses suggest the effects of RANK and RANKL on age at menarche in Chinese women.Climacteric : the journal of the International Menopause Society · 2012Article
- The timing of the age at which natural menopause occurs.Obstetrics and gynecology clinics of North America · 2011Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveMenarche and menopause mark the lower and upper limits of the female reproductive period. The timing of these events influences women's health in later life. The onsets of menarche and menopause have a strong genetic basis. We tested two genes, TNFRSF11A (RANK) and TNFSF11 (RANKL), for their association with age at menarche (AM) and age at natural menopause (ANM).
methodsNineteen single nucleotide polymorphisms (SNPs) of TNFRSF11A and 12 SNPs of TNFSF11 were genotyped in a random sample of 306 unrelated white women. This sample was analyzed for the association of the SNPs and common haplotypes with AM. Then, a subsample of 211 women with natural menopause was analyzed for the association of both genes with ANM. Smoking, alcohol intake, and duration of lactation were applied as covariates in the association analyses.
resultsThree polymorphisms of TNFSF11 were associated with AM: rs2200287 (P = 0.005), rs9525641 (P = 0.039), and rs1054016 (P = 0.047). Two SNPs of this gene, rs346578 and rs9525641, showed an association with ANM (P = 0.007 and P = 0.011, respectively). Two SNPs of TNFRSF11A were associated with AM (rs3826620; P = 0.022) and ANM (rs8086340; P = 0.015). Multiple SNP-SNP and SNP-environment interaction effects on AM and ANM were detected for both genes. One polymorphism of TNFRSF11A, rs4436867, was not directly associated with either trait but indicated significant interactions with four TNFSF11 polymorphisms on ANM. Two other TNFRSF11A polymorphisms, rs4941125 and rs7235803, showed interaction effects with several TNFSF11 polymorphisms on AM. Both genes manifested significant interaction with the duration of breast-feeding in their effect on ANM.
conclusionsThe TNFRSF11A and TNFSF11 genes are associated with the onset of AM and ANM in white women.
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