ArticleJournal of acquired immune deficiency syndromes (1999)2010
Biomarkers of vascular dysfunction in children infected with human immunodeficiency virus-1.
Article in Journal of acquired immune deficiency syndromes (1999), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
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- Trial
- Systemic Inflammation and Growth in Children Born to Mothers With and Without HIV in Rural Zimbabwe.Open forum infectious diseases · 2026Article
- Health-Related Physical Fitness Evaluation in HIV-Diagnosed Children and Adolescents: A Scoping Review.International journal of environmental research and public health · 2024Article
- Monocyte Chemoattractant Protein-1 (MCP-1), Activin-A and Clusterin in Children and Adolescents with Obesity or Type-1 Diabetes Mellitus.Diagnostics (Basel, Switzerland) · 2024Article
- The Role of Inflammation and Immune Activation on Circulating Endothelial Progenitor Cells in Chronic HIV Infection.Frontiers in immunology · 2021Article
- Rethinking COVID-19 in children: Lessons learned from pediatric viral and inflammatory cardiovascular diseases.Progress in pediatric cardiology · 2020Article
- Elevated Lipoprotein(a) in Perinatally HIV-Infected Children Compared With Healthy Ethnicity-Matched Controls.Open forum infectious diseases · 2019Article
- Article
- A multicenter study of diet quality on birth weight and gestational age in infants of HIV-infected women.Maternal & child nutrition · 2017Article
- Hepatic, Renal, Hematologic, and Inflammatory Markers in HIV-Infected Children on Long-term Suppressive Antiretroviral Therapy.Journal of the Pediatric Infectious Diseases Society · 2017Article
- HIV Infection and Carotid Artery Intima-media Thickness: Pooled Analyses Across 5 Cohorts of the NHLBI HIV-CVD Collaborative.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016Article
- Article
- Body mass index and waist circumference of HIV-infected youth in a Miami cohort: comparison to local and national cohorts.Journal of pediatric gastroenterology and nutrition · 2014Article
- Echocardiography and carotid intima-media thickness among asymptomatic HIV-infected adolescents in Thailand.AIDS (London, England) · 2014Article
- Biomarkers and neurodevelopment in perinatally HIV-infected or exposed youth: a structural equation model analysis.AIDS (London, England) · 2014Article
- Associations between fibroblast growth factor 23 and cardiac characteristics in pediatric heart failure.Pediatric nephrology (Berlin, Germany) · 2013Article
- Reproductive health decision-making in perinatally HIV-infected adolescents and young adults.Maternal and child health journal · 2013Article
- Cardiac effects in perinatally HIV-infected and HIV-exposed but uninfected children and adolescents: a view from the United States of America.Journal of the International AIDS Society · 2013Review
- Interventions to address chronic disease and HIV: strategies to promote exercise and nutrition among HIV-infected individuals.Current HIV/AIDS reports · 2012Review
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10 authors.
Funding
Abstract
background: We compared biomarkers of vascular dysfunction among HIV-infected children to a demographically similar group of uninfected children and determined factors associated with these biomarkers. METHODS AND
results: We measured several biomarkers of vascular dysfunction: C-reactive protein (CRP), interleukin-6 (IL-6), and monocyte chemoattractant protein -1 (MCP-1) (inflammation); fibrinogen and P-selectin (coagulant dysfunction); soluble intracellular cell adhesion molecule-1 (sICAM), soluble vascular cell adhesion molecule-1 (sVCAM), and E-selectin (endothelial dysfunction); and leptin (metabolic dysfunction). Anthropometry, body composition, CD4%, HIV viral load, and antiretroviral therapy were recorded. Mean age was 14.8 years (106 HIV-infected children) and 12.3 years (55 control children). Sex and body mass index Z scores were similar. Infected children had higher sICAM, sVCAM, MCP-1, IL-6, and fibrinogen levels. E-selectin (P = 0.07), and CRP (P = 0.08) trended to be greater in the HIV group, yet leptin and P-selectin were similar. In multivariable analyses in the HIV-infected children alone, each 1 standard deviation increase in waist to hip ratio was associated with increases in sICAM (17%), MCP-1 (19%), IL6 (18%), and CRP (59%). CD4% was inversely associated with sVCAM, MCP-1, IL6, fibrinogen, and CRP.
conclusions: HIV-infected children have higher levels of biomarkers of vascular dysfunction than healthy children. Risk factors associated with these biomarkers include higher waist to hip ratios and HIV disease severity.
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