ArticleBlood2010
Identifying drugs that cause acute thrombocytopenia: an analysis using 3 distinct methods.
Article in Blood, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 146 citations in OpenAlex.
- A systematic evaluation of laboratory testing for drug-induced immune thrombocytopenia.Journal of thrombosis and haemostasis : JTH · 2013Pooled it
- Drug-induced thrombocytopenia: an updated systematic review, 2010.Drug safety · 2011Pooled it
- The potential of antimicrobials to induce thrombocytopenia in critically ill patients: data from a randomized controlled trial.PloS one · 2013Trial
- Article
- Intravenous Thiamine-Induced Thrombocytopenia in a Patient With Chronic Adrenal Insufficiency.Journal of medical cases · 2026Article
- The evolving landscape of platelet therapy: risks, innovations, and clinical judgment.Annals of hematology · 2026Review
- The Differential Diagnosis of Thromobocytopenia.Deutsches Arzteblatt international · 2025Review
- Development and external validation of a machine learning model for predicting drug-induced immune thrombocytopenia in a real-world hospital cohort.BMC medical informatics and decision making · 2025Article
- Differentiation of antimicrobial toxicity and sepsis-induced disseminated intravascular coagulation in an orthopedic burn patient in India: a case report.Journal of trauma and injury · 2025Article
- A Case of COVID-19-Induced Immune Thrombocytopenia (ITP) in an Adult Female: An Under-Recognized Emerging Phenomenon.Cureus · 2023Article
- Cross-reactivity between piperacillin-tazobactam and cefoperazone-sulbactam in drug-induced immune thrombocytopenia.The Journal of international medical research · 2023Article
- A Case Report of Ticagrelor-Induced Thrombocytopenia.International medical case reports journal · 2023Article
- Treatment of chemotherapy-induced thrombocytopenia in patients with non-hematologic malignancies.Haematologica · 2022Article
- Bioactive Molecules Derived from Snake Venoms with Therapeutic Potential for the Treatment of Thrombo-Cardiovascular Disorders Associated with COVID-19.The protein journal · 2021Review
- Roxithromycin-Associated Acute Thrombocytopenia.The American journal of case reports · 2021Article
- Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune checkpoint inhibitor-related adverse events.Journal for immunotherapy of cancer · 2021Article
- Treatment with eltrombopag of severe immune thrombocytopenia and hemolytic anemia associated with COVID-19 pneumonia: a case report.Therapeutic advances in hematology · 2021Article
- Detection of Drug-Induced Thrombocytopenia Signals in Children Using Routine Electronic Medical Records.Frontiers in pharmacology · 2021Article
- Platelet transfusion refractoriness: how do I diagnose and manage?Hematology. American Society of Hematology. Education Program · 2020Review
- Naproxen-induced thrombocytopenia.Proceedings (Baylor University. Medical Center) · 2020Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Drug-induced immune thrombocytopenia (DITP) is often suspected in patients with acute thrombocytopenia unexplained by other causes, but documenting that a drug is the cause of thrombocytopenia can be challenging. To provide a resource for diagnosis of DITP and for drug safety surveillance, we analyzed 3 distinct methods for identifying drugs that may cause thrombocytopenia. (1) Published case reports of DITP have described 253 drugs suspected of causing thrombocytopenia; using defined clinical criteria, 87 (34%) were identified with evidence that the drug caused thrombocytopenia. (2) Serum samples from patients with suspected DITP were tested for 202 drugs; drug-dependent, platelet-reactive antibodies were identified for 67 drugs (33%). (3) The Food and Drug Administration's Adverse Event Reporting System database was searched for drugs associated with thrombocytopenia by use of data mining algorithms; 1444 drugs had at least 1 report associated with thrombocytopenia, and 573 (40%) drugs demonstrated a statistically distinctive reporting association with thrombocytopenia. Among 1468 drugs suspected of causing thrombocytopenia, 102 were evaluated by all 3 methods, and 23 of these 102 drugs had evidence for an association with thrombocytopenia by all 3 methods. Multiple methods, each with a distinct perspective, can contribute to the identification of drugs that can cause thrombocytopenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.