ArticleThe Plant cell2010
A vacuolar arsenite transporter necessary for arsenic tolerance in the arsenic hyperaccumulating fern Pteris vittata is missing in flowering plants.
Article in The Plant cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 268 citations in OpenAlex.
- Arsenic-sensing domain controls ACR3 transporter trafficking in Marchantia polymorpha.The Plant cell · 2026Article
- Arsenic efflux mechanisms in ectomycorrhizal mushrooms Hebeloma bulbiferum and Hebeloma sinapizans.Applied microbiology and biotechnology · 2026Article
- PromoterEco-Environment & Health · 2025Article
- Efficient gene editing of a model fern species through gametophyte-based transformation.Plant physiology · 2024Article
- Multilevel Regulation of Membrane Proteins in Response to Metal and Metalloid Stress: A Lesson from Yeast.International journal of molecular sciences · 2024Review
- Review
- A review on arsenic in the environment: bio-accumulation, remediation, and disposal.RSC advances · 2023Review
- Negative Impacts of Arsenic on Plants and Mitigation Strategies.Plants (Basel, Switzerland) · 2023Review
- Genetic Approaches for Iron and Zinc Biofortification and Arsenic Decrease in Oryza sativa L. Grains.Biological trace element research · 2022Review
- Review
- Molecular insight into arsenic uptake, transport, phytotoxicity, and defense responses in plants: a critical review.Planta · 2022Review
- Metal Detoxification in Land Plants: From Bryophytes to Vascular Plants. STATE of the Art and Opportunities.Plants (Basel, Switzerland) · 2022Review
- Safe, efficient, and economically beneficial remediation of arsenic-contaminated soil: possible strategies for increasing arsenic tolerance and accumulation in non-edible economically important native plants.Environmental science and pollution research international · 2021Review
- Review
- Application ofAntioxidants (Basel, Switzerland) · 2021Review
- Charting the genomic landscape of seed-free plants.Nature plants · 2021Review
- Synchrotron micro-X-ray fluorescence imaging of arsenic in frozen-hydrated sections of a root of Pteris vittata.Metallomics : integrated biometal science · 2021Article
- Ionomic variation in leaves of 819 plant species growing in the botanical garden of Hokkaido University, Japan.Journal of plant research · 2021Article
- Pteridophytes in phytoremediation.Environmental geochemistry and health · 2020Review
- PIN FORMED 2 Modulates the Transport of Arsenite inPlant communications · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The fern Pteris vittata tolerates and hyperaccumulates exceptionally high levels of the toxic metalloid arsenic, and this trait appears unique to the Pteridaceae. Once taken up by the root, arsenate is reduced to arsenite as it is transported to the lamina of the frond, where it is stored in cells as free arsenite. Here, we describe the isolation and characterization of two P. vittata genes, ACR3 and ACR3;1, which encode proteins similar to the ACR3 arsenite effluxer of yeast. Pv ACR3 is able to rescue the arsenic-sensitive phenotypes of yeast deficient for ACR3. ACR3 transcripts are upregulated by arsenic in sporophyte roots and gametophytes, tissues that directly contact soil, whereas ACR3;1 expression is unaffected by arsenic. Knocking down the expression of ACR3, but not ACR3;1, in the gametophyte results in an arsenite-sensitive phenotype, indicating that ACR3 plays a necessary role in arsenic tolerance in the gametophyte. We show that ACR3 localizes to the vacuolar membrane in gametophytes, indicating that it likely effluxes arsenite into the vacuole for sequestration. Whereas single-copy ACR3 genes are present in moss, lycophytes, other ferns, and gymnosperms, none are present in angiosperms. The duplication of ACR3 in P. vittata and the loss of ACR3 in angiosperms may explain arsenic tolerance in this unusual group of ferns while precluding the same trait in angiosperms.
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Registered trials
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