Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2010
Biobehavioral, immune, and health benefits following recurrence for psychological intervention participants.
Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 79 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Psychosocial Interventions and Immune System Function: A Systematic Review and Meta-analysis of Randomized Clinical Trials.JAMA psychiatry · 2020Pooled it
- Effectiveness of Stress-Reducing Interventions on the Response to Challenges to the Immune System: A Meta-Analytic Review.Psychotherapy and psychosomatics · 2019Pooled it
- Screening, assessment, and care of anxiety and depressive symptoms in adults with cancer: an American Society of Clinical Oncology guideline adaptation.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Guideline
- Pilot clinical trial of a clinical meditation and imagery intervention for chronic pain after spinal cord injury.The journal of spinal cord medicine · 2022Trial
- Examining key sociodemographic characteristics of adolescents and young adults with cancer: A post hoc analysis of the Promoting Resilience in Stress Management randomized clinical trial.Palliative medicine · 2020Trial
- Effect of the Promoting Resilience in Stress Management Intervention for Parents of Children With Cancer (PRISM-P): A Randomized Clinical Trial.JAMA network open · 2019Trial
- Relationship between social support, quality of life, and Th2 cytokines in a biobehavioral cancer survivorship trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Trial
- Exploratory analysis of treatment response trajectories in the PRISM trial: Models of psychosocial care.Psycho-oncology · 2019Trial
- Lemons to lemonade: Effects of a biobehavioral intervention for cancer patients on later life changes.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Trial
- Hope and benefit finding: Results from the PRISM randomized controlled trial.Pediatric blood & cancer · 2019Trial
- Distress is Interdependent in Patients and Caregivers with Newly Diagnosed Incurable Cancers.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2017Trial
- Stress management, leukocyte transcriptional changes and breast cancer recurrence in a randomized trial: An exploratory analysis.Psychoneuroendocrinology · 2016Trial
- Examining Mediators and Moderators of Yoga for Women With Breast Cancer Undergoing Radiotherapy.Integrative cancer therapies · 2016Trial
- A randomized trial comparing live and telemedicine deliveries of an imagery-based behavioral intervention for breast cancer survivors: reducing symptoms and barriers to care.Psycho-oncology · 2015Trial
- Psychosocial telephone counseling for survivors of cervical cancer: results of a randomized biobehavioral trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Trial
- Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.Biological psychiatry · 2012Trial
- Decrease in depression symptoms is associated with longer survival in patients with metastatic breast cancer: a secondary analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2011Trial
- Evaluating the effectiveness and implementation of evidence-based treatment: A multisite hybrid design.The American psychologistTrial
- Peripheral Nerve-Cancer Interactions in the Tumor Microenvironment: A Three-Dimensional Framework Integrating Mechanisms, Modulators, and Therapeutic Strategies.Research (Washington, D.C.) · 2026Review
- Neuroimmune Interactions in Pancreatic Cancer.Biomedicines · 2025Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
purposeA clinical trial was designed to test the hypothesis that a psychological intervention could reduce the risk of cancer recurrence. Newly diagnosed regional breast cancer patients (n = 227) were randomized to the intervention-with-assessment or the assessment-only arm. The intervention had positive psychological, social, immune, and health benefits, and after a median of 11 years the intervention arm was found to have reduced the risk of recurrence (hazard ratio, 0.55; P = 0.034). In follow-up, we hypothesized that the intervention arm might also show longer survival after recurrence. If observed, we then would examine potential biobehavioral mechanisms. EXPERIMENTAL
designAll patients were followed; 62 recurred. Survival analyses included all 62. Upon recurrence diagnosis, those available for further biobehavioral study were accrued (n = 41, 23 intervention and 18 assessment). For those 41, psychological, social, adherence, health, and immune (natural killer cell cytotoxicity, T-cell proliferation) data were collected at recurrence diagnosis and 4, 8, and 12 months later.
resultsIntent-to-treat analysis revealed reduced risk of death following recurrence for the intervention arm (hazard ratio, 0.41; P = 0.014). Mixed-effects follow-up analyses with biobehavioral data showed that all patients responded with significant psychological distress at recurrence diagnosis, but thereafter only the intervention arm improved (P values < 0.023). Immune indices were significantly higher for the intervention arm at 12 months (P values < 0.017).
conclusionsHazards analyses augment previous findings in showing improved survival for the intervention arm after recurrence. Follow-up analyses showing biobehavioral advantages for the intervention arm contribute to our understanding of how improved survival was achieved.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.