ArticleCancer research2010
Colorectal cancer incidence trends in the United States and United kingdom: evidence of right- to left-sided biological gradients with implications for screening.
Article in Cancer research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 3 of them syntheses that pooled it.
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Who cites it
72 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review of methods to estimate colorectal cancer incidence using population-based cancer registries.BMC medical research methodology · 2022Pooled it
- Statistical methods for measuring trends in colorectal cancer incidence in registries: A systematic review.Frontiers in oncology · 2022Pooled it
- Laparoscopic versus open colorectal resection in the elderly population.Surgical endoscopy · 2013Pooled it
- Sex Differences in Colorectal Tumor-Associated T-cell Responses.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Modeling Early-Onset Cancer Kinetics Reveals Changes in Underlying Risk and the Impact of Population Screening.Cancer research · 2025Article
- Modeling early-onset cancer kinetics to study changes in underlying risk, detection, and impact of population screening.medRxiv : the preprint server for health sciences · 2025Article
- The Value of Primary Tumor Resection in Patients with Liver Metastases: A 10-Year Outcome.Annals of surgical oncology · 2025Article
- Development and validation of an online calculator to predict the pathological nature of colorectal tumors.World journal of gastrointestinal oncology · 2023Article
- Childhood body mass index trajectories, adult-onset type 2 diabetes, and obesity-related cancers.Journal of the National Cancer Institute · 2023Article
- Bile acid distributions, sex-specificity, and prognosis in colorectal cancer.Biology of sex differences · 2022Article
- Modeling age-specific incidence of colon cancer via niche competition.PLoS computational biology · 2022Article
- Molecular Biologic and Epidemiologic Insights for Preventability of Colorectal Cancer.Journal of the National Cancer Institute · 2022Article
- New considerations for colorectal cancer screening based on the demographic profile of colorectal cancer in a Greek population.Molecular and clinical oncology · 2022Article
- Weight Changes in Type 2 Diabetes and Cancer Risk: A Latent Class Trajectory Model Study.Obesity facts · 2022Article
- Effect of Primary Tumor Location on Second- or Later-Line Treatment With Anti-Epidermal Growth Factor Receptor Antibodies in Patients With Metastatic Colorectal Cancer: A Retrospective Multi-Center Study.Frontiers in oncology · 2022Article
- Identification of two methylated fragments of an SDC2 CpG island using a sliding window technique for early detection of colorectal cancer.FEBS open bio · 2021Article
- Modeling historic incidence trends implies early field cancerization in esophageal squamous cell carcinoma.PLoS computational biology · 2021Article
- Effect of hematopoietic progenitor cells on the biological characteristics of colon cancer tumor stem cells.Translational cancer research · 2021Article
- Methylation ofFrontiers in molecular biosciences · 2021Article
- The effect of educational intervention based on theory of planned behavior on the improvement of colorectal cancer screening intention among average-risk individuals referring to Asadabad city clinics.Journal of education and health promotion · 2021Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
Several lines of evidence support the premise that screening colonoscopy reduces colorectal cancer (CRC) incidence, but there may be differential benefits for right- and left-sided tumors. To better understand the biological basis of this differential effect, we derived biomathematical models of CRC incidence trends in U.S. and U.K. populations, representing relatively high- and low-prevalence screening, respectively. Using the Surveillance Epidemiology and End Results (SEER) and the Office for National Statistics (ONS) registries (both 1973-2006), we derived stochastic multistage clonal expansion (MSCE) models for right-sided (proximal colon) and left-sided (distal colon and rectal) tumors. The MSCE concept is based on the initiation-promotion-progression paradigm of carcinogenesis and provides a quantitative description of natural tumor development from the initiation of an adenoma (via biallelic tumor suppressor gene inactivation) to the clinical detection of CRC. From 1,228,036 (SEER: 340,582; ONS: 887,454) cases, parameter estimates for models adjusted for calendar-year and birth-cohort effects showed that adenoma initiation rates were higher for right-sided tumors, whereas, paradoxically, adenoma growth rates were higher for left-sided tumors. The net effect was a higher cancer risk in the right colon only after age 70 years. Consistent with this finding, simulations of adenoma development predicted that the relative prevalence for right- versus left-sided tumors increases with increasing age, a differential effect most striking in women. Using a realistic biomathematical description of CRC development for two nationally representative registries, we show age- and sex-dependent biological gradients for right- and left-sided colorectal tumors. These findings argue for an age-, sex-, and site-directed approach to CRC screening.
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