ArticleJournal of cell science2010
Phosphorylation regulates polarisation of chitin synthesis in Candida albicans.
Article in Journal of cell science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Phosphoproteomics of WHO-Priority Fungal Pathogens: Conserved Signaling Architecture, Pathogen-Specific Outputs, and Therapeutic Vulnerabilities.Pathogens (Basel, Switzerland) · 2026Review
- Fungal Chitin Synthases: Structure, Function, and Regulation.Journal of fungi (Basel, Switzerland) · 2025Review
- The Putative CytochromeJournal of fungi (Basel, Switzerland) · 2024Article
- The N-terminal disordered region of ChsB regulates its efficient transport to the hyphal apical surface in Aspergillus nidulans.Current genetics · 2023Article
- Local calcium signal transmission in mycelial network exhibits decentralized stress responses.PNAS nexus · 2023Article
- The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence.Cell reports · 2021Article
- Scalar nanostructure of theCell surface (Amsterdam, Netherlands) · 2020Article
- Off the wall: The rhyme and reason ofCell surface (Amsterdam, Netherlands) · 2019Review
- Priming and elongation of chitin chains: Implications for chitin synthase mechanism.Cell surface (Amsterdam, Netherlands) · 2019Article
- Exposure of Candida albicans β (1,3)-glucan is promoted by activation of the Cek1 pathway.PLoS genetics · 2019Article
- The Functional Specialization of Exomer as a Cargo Adaptor During the Evolution of Fungi.Genetics · 2018Article
- Article
- Cell wall protection by the Candida albicans class I chitin synthases.Fungal genetics and biology : FG & B · 2015Article
- Article
- Putative chitin synthases from Branchiostoma floridae show extracellular matrix-related domains and mosaic structures.Genomics, proteomics & bioinformatics · 2012Article
- Regulation of expression, activity and localization of fungal chitin synthases.Medical mycology · 2012Review
- Growth of Candida albicans hyphae.Nature reviews. Microbiology · 2011Review
- Chitin synthesis and fungal pathogenesis.Current opinion in microbiology · 2010Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The ability to undergo polarised cell growth is fundamental to the development of almost all walled organisms. Fungi are characterised by yeasts and moulds, and both cellular forms have been studied extensively as tractable models of cell polarity. Chitin is a hallmark component of fungal cell walls. Chitin synthesis is essential for growth, viability and rescue from many conditions that impair cell-wall integrity. In the polymorphic human pathogen Candida albicans, chitin synthase 3 (Chs3) synthesises the majority of chitin in the cell wall and is localised at the tips of growing buds and hyphae, and at the septum. An analysis of the C. albicans phospho-proteome revealed that Chs3 can be phosphorylated at Ser139. Mutation of this site showed that both phosphorylation and dephosphorylation are required for the correct localisation and function of Chs3. The kinase Pkc1 was not required to target Chs3 to sites of polarised growth. This is the first report demonstrating an essential role for chitin synthase phosphorylation in the polarised biosynthesis of fungal cell walls and suggests a new mechanism for the regulation of this class of glycosyl-transferase enzyme.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.