ArticleDevelopment (Cambridge, England)2010
Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- mRNA Editing, Processing and Quality Control inGenetics · 2020Review
- Casein Kinase 1δ Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin.Developmental cell · 2020Article
- Widespread Translational Remodeling during Human Neuronal Differentiation.Cell reports · 2017Article
- Tissue-specific regulation of alternative polyadenylation represses expression of a neuronal ankyrin isoform inDevelopment (Cambridge, England) · 2017Article
- Release-dependent feedback inhibition by a presynaptically localized ligand-gated anion channel.eLife · 2016Article
- The Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice.PloS one · 2016Article
- Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development.Genes & development · 2015Article
- Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation.RNA (New York, N.Y.) · 2014Article
- CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processing.Genes & development · 2014Article
- Insights into the functions of the death associated protein kinases from C. elegans and other invertebrates.Apoptosis : an international journal on programmed cell death · 2014Review
- Regulatory roles of RNA binding proteins in the nervous system of C. elegans.Frontiers in molecular neuroscience · 2014Review
- Hyperactivation of B-type motor neurons results in aberrant synchrony of the Caenorhabditis elegans motor circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Expanding views of presynaptic terminals: new findings from Caenorhabditis elegans.Current opinion in neurobiology · 2012Review
- The wounded worm: Using C. elegans to understand the molecular basis of skin wound healing.Worm · 2012Article
- The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
5 authors.
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Abstract
Nuclear pre-mRNA 3'-end processing is vital for the production of mature mRNA and the generation of the 3' untranslated region (UTR). However, the roles and regulation of this event in cellular development remain poorly understood. Here, we report the function of a nuclear pre-mRNA 3'-end processing pathway in synapse and axon formation in C. elegans. In a genetic enhancer screen for synaptogenesis mutants, we identified a novel polyproline-rich protein, Synaptic defective enhancer-1 (SYDN-1). Loss of function of sydn-1 causes abnormal synapse and axon development, and displays striking synergistic interactions with several genes that regulate specific aspects of synapses. SYDN-1 is required in neurons and localizes to distinct regions of the nucleus. Through a genetic suppressor screen, we found that the neuronal defects of sydn-1 mutants are suppressed by loss of function in Polyadenylation factor subunit-2 (PFS-2), a conserved WD40-repeat protein that interacts with multiple subcomplexes of the pre-mRNA 3'-end processing machinery. PFS-2 partially colocalizes with SYDN-1, and SYDN-1 influences the nuclear abundance of PFS-2. Inactivation of several members of the nuclear 3'-end processing complex suppresses sydn-1 mutants. Furthermore, lack of sydn-1 can increase the activity of 3'-end processing. Our studies provide in vivo evidence for pre-mRNA 3'-end processing in synapse and axon development and identify SYDN-1 as a negative regulator of this cellular event in neurons.
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