ArticleDevelopment (Cambridge, England)2010
doublesex/mab3 related-1 (dmrt1) is essential for development of anterior neural plate derivatives in Ciona.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- An NKX2-3/5/6 homolog is required downstream of BMP signaling to pattern the sensory-adhesive organ of a tunicate larva.PLoS genetics · 2026Article
- An NKX2-5 homolog is required downstream of BMP signaling to pattern the sensory-adhesive organ of a tunicate larva.bioRxiv : the preprint server for biology · 2025Article
- Motor neurons in the tunicate caudal central nervous system reveal homology to the vertebrate spinal cord.Development (Cambridge, England) · 2025Article
- Deep homologies in chordate caudal central nervous systems.bioRxiv : the preprint server for biology · 2024Article
- A single oscillating proto-hypothalamic neuron gates taxis behavior in the primitive chordate Ciona.Current biology : CB · 2023Article
- A single oscillating proto-hypothalamic neuron gates taxis behavior in the primitive chordatebioRxiv : the preprint server for biology · 2023Article
- DMRT Transcription Factors in the Control of Nervous System Sexual Differentiation.Frontiers in neuroanatomy · 2022Review
- DMD-10 is dispensable for the initial development of amphid sensory neurons and their survival in maturemicroPublication biology · 2021Article
- The Doublesex/Mab-3 domain transcription factor DMD-10 regulates ASH-dependent behavioral responses.PeerJ · 2021Article
- Fold Change Detection in Visual Processing.Frontiers in neural circuits · 2021Article
- High-resolution 3D fluorescent imaging of intact tissues.International journal of cardiology and cardiovascular diseases · 2021Article
- TheFrontiers in cell and developmental biology · 2020Article
- A Nearly Complete Genome of Ciona intestinalis Type A (C. robusta) Reveals the Contribution of Inversion to Chromosomal Evolution in the Genus Ciona.Genome biology and evolution · 2019Article
- Article
- Differential gene expression along the animal-vegetal axis in the ascidian embryo is maintained by a dual functional protein Foxd.PLoS genetics · 2017Article
- Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- ACAM, a novel member of the neural IgCAM family, mediates anterior neural tube closure in a primitive chordate.Developmental biology · 2016Article
- T-type Calcium Channel Regulation of Neural Tube Closure and EphrinA/EPHA Expression.Cell reports · 2015Article
- Diverse ETS transcription factors mediate FGF signaling in the Ciona anterior neural plate.Developmental biology · 2015Article
- Gene regulatory systems that control gene expression in the Ciona embryo.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2015Review
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8 authors.
Funding
Abstract
Ascidian larvae have a hollow, dorsal central nervous system that shares many morphological features with vertebrate nervous systems yet is composed of very few cells. We show here that a null mutation in the gene dmrt1 in the ascidian Ciona savignyi results in profound abnormalities in the development of the sensory vesicle (brain), as well as other anterior ectodermal derivatives, including the palps and oral siphon primordium (OSP). Although the phenotype of the mutant embryos is variable, the majority have a complete loss of the most anterior structures (palps and OSP) and extensive disruption of sensory structures, such as the light-sensitive ocellus, in the sensory vesicle. dmrt1 is expressed early in the blastula embryo in a small group of presumptive ectodermal cells as they become restricted to anterior neural, OSP and palp fates. Despite the early and restricted expression of dmrt1, we were unable, using several independent criteria, to observe a defect in the mutant embryos until the early tailbud stage. We speculate that the variability and late onset in the phenotype may be due to partially overlapping activities of other gene products.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.