ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2010
Short-term hypoxia increases tyrosine hydroxylase immunoreactivity in rat carotid body.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Increased Fos immunoreactivity in astrocytes in the raphe pallidus under hypoxia, not hypercapnia.Histochemistry and cell biology · 2025Article
- Distribution and morphology of serotonin transporter-immunoreactive type I cells in the rat carotid body.Anatomical record (Hoboken, N.J. : 2007) · 2025Article
- Comparative exploration of the carotid body in domestic animals: morphology, physiology, histology, and pathology.Frontiers in veterinary science · 2024Review
- Structural Plasticity of the Carotid Body.Advances in anatomy, embryology, and cell biology · 2023Article
- Neurochemical Plasticity of the Carotid Body.Advances in anatomy, embryology, and cell biology · 2023Article
- n-Propanol extract of boiled and fermented koro benguk (Veterinary world · 2018Article
- Short-term hypoxia transiently increases dopamine β-hydroxylase immunoreactivity in glomus cells of the rat carotid body.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- Ventilatory behavior and carotid body morphology of Brown Norway and Sprague Dawley rats.Respiratory physiology & neurobiology · 2011Article
- Hypoxia. 3. Hypoxia and neurotransmitter synthesis.American journal of physiology. Cell physiology · 2011Review
- Comorbidities Among Persons With Incident Psychiatric Condition.Gerontology & geriatric medicineArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Neurochemical and morphological changes in the carotid body are induced by chronic hypoxia, leading to regulation of ventilation. In this study, we examined the time courses of changes in immunohistochemical intensity for tyrosine hydroxylase (TH) and cellular volume of glomus cells in rats exposed to hypoxia (10% O(2)) for up to 24 hr. Grayscale intensity for TH immunofluorescence was significantly increased in rats exposed to hypoxia for 12, 18, and 24 hr compared with control rats (p<0.05). The transectional area of glomus cells was not significantly different between experimental groups. The TH fluorescence intensity of the glomus cells exhibited a strong negative correlation with the transectional area in control rats (Spearman's rho = -0.70). This correlation coefficient decreased with exposure time, and it was lowest for the rats exposed to hypoxia for 18 hr (rho = -0.18). The histogram of TH fluorescence intensity showed a single peak in control rats. The peaks were gradually shifted to the right and became less pronounced in hypoxia-exposed rats, suggesting that a hypoxia-induced increase in TH immunoreactivity occurred uniformly in glomus cells. In conclusion, this study demonstrates that short-term hypoxia induces an increase in TH protein expression in rat carotid body glomus cells.
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