ArticleThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society2010
Spexin expression in normal rat tissues.
Article in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed.
- Spexin Attenuates Cerebral Ischemia-Reperfusion-Induced Brain Injury in Rats via Suppression of NF-κB-Associated Inflammation and Apoptosis.Molecular neurobiology · 2026Article
- Therapeutic potential of spexin in diabetic neuropathy: Insights from in vitro and in vivo models.Experimental physiology · 2026Article
- Spexin disrupts migrating myoelectric complex in the rat small intestine: The role of galanin-2 and muscarinic receptors.Pflugers Archiv : European journal of physiology · 2026Article
- Time-dependent integrated tissue and circulating biomarker dynamics of spexin and progranulin in an experimental myocardial infarction model.Histochemistry and cell biology · 2026Article
- Nephroprotective effect of spexin in dogs and cats.BMC veterinary research · 2026Article
- Inhibition of galanin receptor 3 slows down retina degeneration in retinitis pigmentosa through modulation of inflammatory and oxidative stress response.Scientific reports · 2026Article
- Emerging roles of spexin in cardiovascular homeostasis.Frontiers in cardiovascular medicine · 2026Review
- Effect of vitamin D and location of asprosin, spexin and meteorin-like antibodies in the liver of rats with isoproterenol-induced myocardial infarction.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Evaluating plasma phoenixin-14, galanin, galanin-like peptide, and spexin levels in polycystic ovary syndrome.Irish journal of medical science · 2025Article
- Spexin-Mediated Dietary Adaptation inAnimals : an open access journal from MDPI · 2025Article
- Associations Between Circulating Spexin, Obesity, and Insulin Resistance in Korean Children and Adolescents.Nutrients · 2025Article
- High intensity interval training attenuate insulin resistance in diabetic rats accompanied by improvements in liver metabolism and spexin signaling.Scientific reports · 2025Article
- Involvement of central opioid and melanocortin receptors in spexin-induced hypophagia following intracerebroventricular injection in neonatal broiler chicks.BMC veterinary research · 2025Article
- Spexin Adipokinin and TRPM2 ION Channel in Lung Cancer Use as a Bıomarker in Hıstopathologic Diagnosis.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Immunohistochemical investigation of transient receptor potential melastatin-2 and spexin immunoreactivity in atopic dermatitis and mycosis fungoides.Archives of dermatological research · 2025Article
- Role of spexin and DARS2 as potential biomarkers in basal cell carcinoma and cutaneous malignant melanoma diagnosis, and as therapeutic targets.Archives of dermatological research · 2024Article
- Role of Spexin in White Adipose Tissue Thermogenesis under Basal and Cold-Stimulated Conditions.International journal of molecular sciences · 2024Article
- Advances in research on spexin-mediated regulation of reproductive function in vertebrates.Frontiers in endocrinology · 2024Review
- Serum Spexin Level Is Negatively Associated With Peripheral Neuropathy and Sensory Pain in Type 2 Diabetes.Journal of diabetes research · 2024Article
- Effects of N-acetylcysteine on spexin immunoreactivity in kidney tissues of rats treated with adriamycin.Iranian journal of basic medical sciences · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spexin is a highly conserved peptide which was recently identified through the bioinformatics approach. Immunohistochemical analysis of its expression has not yet been performed. Thus, in this study, we examined spexin location in a wide range of rat organs by both RT-PCR and IHC. RT-PCR identified spexin mRNA in all tissues examined. Spexin immunoreaction was mainly cytoplasmic. Spexin was immunohistochemically detected, although with different staining intensities, in epithelia and glands of skin and respiratory, digestive, urinary, and reproductive systems. Smooth muscle cells showed weak immunostaining, and connective tissue was negative. In the central nervous system, neuronal groups showed different intensities for reaction product. Immunoreaction was also found in ganglionic cells of both trigeminal and superior cervical ganglia and in photoreceptor, inner nuclear, and ganglionic layers of the retina. In the endocrine system, spexin immunoreaction was detected in the hypothalamic paraventricular and supraoptic nuclei; adenohypophysis, thyroid, and parathyroid glands; adrenal cortex and medulla (mainly ganglionic cells); Leydig cells; and thecal, luteal, and interstitial cells of the ovary. Because of its widespread expression, spexin is probably involved in many different physiological functions; in particular, location of spexin in neurons and endocrine cells suggests its roles as neurotransmitter/neuromodulator and endocrine factor.
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