ArticleChemical senses2010
Detection of volatile indicators of illicit substances by the olfactory receptors of Drosophila melanogaster.
Article in Chemical senses, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
- Molecular bases of insect odorant receptor function: specificity and evolution.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Illicit Drug-Derived Volatile Organic Compounds as Markers for Application in Noncontact Detection Technology.Chemical record (New York, N.Y.) · 2026Review
- Engineered Metarhizium fungi produce longifolene to attract and kill mosquitoes.Nature microbiology · 2025Article
- Olfactory Receptor Responses to Pure Odorants in Drosophila melanogaster.The European journal of neuroscience · 2025Article
- Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63.Nature communications · 2022Article
- Identification and characterization of CYPs induced in the Drosophila antenna by exposure to a plant odorant.Scientific reports · 2021Article
- The genome of the stable fly, Stomoxys calcitrans, reveals potential mechanisms underlying reproduction, host interactions, and novel targets for pest control.BMC biology · 2021Article
- Sequence-Based Prediction of Olfactory Receptor Responses.Chemical senses · 2019Article
- Evaluation of the DREAM Technique for a High-Throughput Deorphanization of Chemosensory Receptors inFrontiers in molecular neuroscience · 2018Article
- Organization and function ofeLife · 2016Article
- Population differences in olfaction accompany host shift in Drosophila mojavensis.Proceedings. Biological sciences · 2016Article
- Olfactory channels associated with the Drosophila maxillary palp mediate short- and long-range attraction.eLife · 2016Article
- Odorant receptors of Drosophila are sensitive to the molecular volume of odorants.Scientific reports · 2016Article
- DoOR 2.0--Comprehensive Mapping of Drosophila melanogaster Odorant Responses.Scientific reports · 2016Article
- An odor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning.Scientific reports · 2015Article
- An RNA-seq screen of the Drosophila antenna identifies a transporter necessary for ammonia detection.PLoS genetics · 2014Article
- Using insect electroantennogram sensors on autonomous robots for olfactory searches.Journal of visualized experiments : JoVE · 2014Article
- More than apples and oranges--detecting cancer with a fruit fly's antenna.Scientific reports · 2014Article
- Multiphasic on/off pheromone signalling in moths as neural correlates of a search strategy.PloS one · 2013Article
- Behavioural and genetic evidence for C. elegans' ability to detect volatile chemicals associated with explosives.PloS one · 2010Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insects can detect a large range of odors with a numerically simple olfactory system that delivers high sensitivity and accurate discrimination. Therefore, insect olfactory receptors hold great promise as biosensors for detection of volatile organic chemicals in a range of applications. The array of olfactory receptor neurons of Drosophila melanogaster is rapidly becoming the best-characterized natural nose. We have investigated the suitability of Drosophila receptors as detectors for volatiles with applications in law enforcement, emergency response, and security. We first characterized responses of the majority of olfactory neuron types to a set of diagnostic odorants. Being thus able to correctly identify neurons, we then screened for responses from 38 different types of neurons to 35 agents. We identified 13 neuron types with responses to 13 agents. As individual Drosophila receptor genes have been mapped to neuron types, we can infer which genes confer responsiveness to the neurons. The responses were confirmed for one receptor by expressing it in a nonresponsive neuron. The fly olfactory system is mainly adapted to detect volatiles from fermenting fruits. However, our findings establish that volatiles associated with illicit substances, many of which are of nonnatural origin, are also detected by Drosophila receptors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.