ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 123 citations in OpenAlex.
- Mitochondrial asymmetry shifts T cell fate.Nature cell biology · 2026Article
- Control of stress-activated Cdc42 dynamics by the MAP kinase Sty1-NDR kinase Orb6 regulatory axis.iScience · 2025Article
- Review
- The Biological Significance of Trogocytosis.Results and problems in cell differentiation · 2024Article
- Asymmetric T-cell division: insights from cutting-edge experimental techniques and implications for immunotherapy.Frontiers in immunology · 2024Review
- Biased placement of Mitochondria fission facilitates asymmetric inheritance of protein aggregates during yeast cell division.PLoS computational biology · 2023Article
- E-cadherin in developing murine T cells controls spindle alignment and progression through β-selection.Science advances · 2023Article
- Localization of a TORC1-eIF4F translation complex during CD8Molecular cell · 2022Article
- The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Par-3 family proteins in cell polarity & adhesion.The FEBS journal · 2022Review
- Healing Field: Using Alternating Electric Fields to Prevent Cytokine Storm by Suppressing Clonal Expansion of the Activated Lymphocytes in the Blood Sample of the COVID-19 Patients.Frontiers in bioengineering and biotechnology · 2022Article
- Lymphocytes and Trogocytosis-Mediated Signaling.Cells · 2021Review
- The polarity protein PARD3 and cancer.Oncogene · 2021Review
- The chaperonin CCT controls T cell receptor-driven 3D configuration of centrioles.Science advances · 2020Article
- The synergy of damage repair and retention promotes rejuvenation and prolongs healthy lifespans in cell lineages.PLoS computational biology · 2020Article
- Dances with Cells.Critical reviews in immunology · 2020Article
- A Ciliary View of the Immunological Synapse.Cells · 2019Review
- Maps of variability in cell lineage trees.PLoS computational biology · 2019Article
- Polarity as a physiological modulator of cell function.Frontiers in bioscience (Landmark edition) · 2019Review
- Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd.Scientific reports · 2018Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 8 institutions in 2 countries.
Funding
Abstract
Asymmetric cell division is a potential means by which cell fate choices during an immune response are orchestrated. Defining the molecular mechanisms that underlie asymmetric division of T cells is paramount for determining the role of this process in the generation of effector and memory T cell subsets. In other cell types, asymmetric cell division is regulated by conserved polarity protein complexes that control the localization of cell fate determinants and spindle orientation during division. We have developed a tractable, in vitro model of naive CD8(+) T cells undergoing initial division while attached to dendritic cells during Ag presentation to investigate whether similar mechanisms might regulate asymmetric division of T cells. Using this system, we show that direct interactions with APCs provide the cue for polarization of T cells. Interestingly, the immunological synapse disseminates before division even though the T cells retain contact with the APC. The cue from the APC is translated into polarization of cell fate determinants via the polarity network of the Par3 and Scribble complexes, and orientation of the mitotic spindle during division is orchestrated by the partner of inscuteable/G protein complex. These findings suggest that T cells have selectively adapted a number of evolutionarily conserved mechanisms to generate diversity through asymmetric cell division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.