ArticleGenome research2010
Contrasting GC-content dynamics across 33 mammalian genomes: relationship with life-history traits and chromosome sizes.
Article in Genome research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
116 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Article
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- Unravelling Taxonomic Complexity in Elusive Cetaceans: Mitogenome Insights into Evolutionary History and Cryptic Diversity of Bryde's Whales.Ecology and evolution · 2026Article
- Big Spider, Big Genome: Chromosome-Level Genome of a North American Tarantula (Aphonopelma marxi) and Comparative Genomics Across 300 Million Years of Spider Evolution.Genome biology and evolution · 2026Article
- The effect of taxonomic, host-dependent features and sample bias on virus host prediction using machine learning and short sequence k-mers.Scientific reports · 2025Article
- Myxozoan parasite genomes assembled from contaminated host data reveal extensive gene order conservation and rapid sequence evolution.G3 (Bethesda, Md.) · 2025Article
- Compensatory Evolution Following Deleterious Episodes of GC-biased Gene Conversion in Rodents.Molecular biology and evolution · 2025Article
- Interpreting mammalian synonymous site conservation in light of the unwanted transcript hypothesis.Nature communications · 2025Article
- Insight into crRNA Processing inInternational journal of molecular sciences · 2025Article
- The GC% landscape of the Nucleocytoviricota.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Genome and life-history evolution link bird diversification to the end-Cretaceous mass extinction.Science advances · 2024Article
- GC Content Across Insect Genomes: Phylogenetic Patterns, Causes and Consequences.Journal of molecular evolution · 2024Article
- Rapid Targeted Assembly of the Proteome Reveals Evolutionary Variation of GC Content in Avian Lice.Bioinformatics and biology insights · 2024Article
- Statistical analysis of synonymous and stop codons in pseudo-random and real sequences as a function of GC content.Scientific reports · 2023Article
- GC-biased gene conversion drives accelerated evolution of ultraconserved elements in mammalian and avian genomes.Genome research · 2023Article
- Directed stepwise tracing of polysynaptic neuronal circuits with replication-deficient pseudorabies virus.Cell reports methods · 2023Article
- Genome Evolution and the Future of Phylogenomics of Non-Avian Reptiles.Animals : an open access journal from MDPI · 2023Review
- Using combined single-cell gene expression, TCR sequencing and cell surface protein barcoding to characterize and track CD4+ T cell clones from murine tissues.Frontiers in immunology · 2023Article
- DNA sequence features underlying large-scale duplications and deletions in human.Journal of applied genetics · 2022Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The origin, evolution, and functional relevance of genomic variations in GC content are a long-debated topic, especially in mammals. Most of the existing literature, however, has focused on a small number of model species and/or limited sequence data sets. We analyzed more than 1000 orthologous genes in 33 fully sequenced mammalian genomes, reconstructed their ancestral isochore organization in the maximum likelihood framework, and explored the evolution of third-codon position GC content in representatives of 16 orders and 27 families. We showed that the previously reported erosion of GC-rich isochores is not a general trend. Several species (e.g., shrew, microbat, tenrec, rabbit) have independently undergone a marked increase in GC content, with a widening gap between the GC-poorest and GC-richest classes of genes. The intensively studied apes and (especially) murids do not reflect the general placental pattern. We correlated GC-content evolution with species life-history traits and cytology. Significant effects of body mass and genome size were detected, with each being consistent with the GC-biased gene conversion model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.