ArticleAntimicrobial agents and chemotherapy2010
Development, validation, and routine application of a high-performance liquid chromatography method coupled with a single mass detector for quantification of itraconazole, voriconazole, and posaconazole in human plasma.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 57 citations in OpenAlex.
- Validation of a method for itraconazole and major metabolite hydroxyitraconazole for LC-MS/MS analysis with application in a formulation clinical study.Journal of pharmaceutical and biomedical analysis · 2023Article
- Advancing posaconazole quantification analysis with a new reverse-phase HPLC method in its bulk and marketed dosage form.F1000Research · 2023Article
- Assessment of greenness for the determination of voriconazole in reported analytical methods.RSC advances · 2022Review
- Factorial design-assisted reversed phase-high performance liquid chromatography method for simultaneous determination of fluconazole, itraconazole and terbinafine.Royal Society open science · 2021Article
- Effect of Gender and Age on Voriconazole Trough Concentrations in Italian Adult Patients.European journal of drug metabolism and pharmacokinetics · 2020Article
- Therapeutic drug monitoring of voriconazole for treatment and prophylaxis of invasive fungal infection in children.British journal of clinical pharmacology · 2018Article
- Analysis of imidazoles and triazoles in biological samples after MicroExtraction by packed sorbent.Journal of enzyme inhibition and medicinal chemistry · 2017Article
- Evaluation of Posaconazole Pharmacokinetics in Adult Patients with Invasive Fungal Infection.Biomedicines · 2017Article
- Development and Validation of Voriconazole Concentration by LC-MS-MS: Applied in Clinical Implementation.Journal of clinical laboratory analysis · 2017Article
- A simple high-performance liquid chromatography method for simultaneous determination of three triazole antifungals in human plasma.Antimicrobial agents and chemotherapy · 2013Article
- Multiplex ultra-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification in human plasma of fluconazole, itraconazole, hydroxyitraconazole, posaconazole, voriconazole, voriconazole-N-oxide, anidulafungin, and caspofungin.Antimicrobial agents and chemotherapy · 2010Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have developed and validated a high-performance liquid chromatography method coupled with a mass detector to quantify itraconazole, voriconazole, and posaconazole using quinoxaline as the internal standard. The method involves protein precipitation with acetonitrile. Mean accuracy (percent deviation from the true value) and precision (relative standard deviation percentage) were less than 15%. Mean recovery was more than 80% for all drugs quantified. The lower limit of quantification was 0.031 microg/ml for itraconazole and posaconazole and 0.039 microg/ml for voriconazole. The calibration range tested was from 0.031 to 8 microg/ml for itraconazole and posaconazole and from 0.039 to 10 microg/ml for voriconazole.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.