SynthesisCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2010
Diagnostic accuracy of the TIMI risk score in patients with chest pain in the emergency department: a meta-analysis.
Synthesis in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Age-adjusted quick Sequential Organ Failure Assessment score for predicting mortality and disease severity in children with infection: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
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- The Value of BISAP Score for Predicting Mortality and Severity in Acute Pancreatitis: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
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- Assessment and Application of the Hear Score in Remote Emergency Medicine Outposts in Bosnia and Herzegovina.Medicina (Kaunas, Lithuania) · 2024Article
- ChatGPT provides inconsistent risk-stratification of patients with atraumatic chest pain.PloS one · 2024Article
- Interrelation between hypoxic liver injury and Killip classification in ST-segment elevation myocardial infarction patients.Frontiers in cardiovascular medicine · 2024Article
- Performance of the Risk Scores for Predicting In-Hospital Mortality in Patients with Acute Coronary Syndrome in a Chinese Cohort.Reviews in cardiovascular medicine · 2023Article
- Risk Prediction Models for Ischemic Cardiovascular Outcomes in Patients with Acute Coronary Syndrome.Reviews in cardiovascular medicine · 2023Review
- Snapshot of suspected acute coronary syndrome assessment processes in the emergency department: A national cross-sectional survey.Emergency medicine Australasia : EMA · 2023Article
- Use of Coronary CT Angiography to Predict Obstructive Lesions in Patients with Chest Pain without Enzyme and ST-Segment Elevation.Journal of clinical medicine · 2021Article
- 30 day predicted outcome in undifferentiated chest pain: multicenter validation of the HEART score in Tunisian population.BMC cardiovascular disorders · 2021Article
- Previously undiagnosed scoliosis presenting as pleuritic chest pain in the emergency department - a case series and a validating retrospective audit.BMC emergency medicine · 2021Article
- In Search of an Optimal Subset of ECG Features to Augment the Diagnosis of Acute Coronary Syndrome at the Emergency Department.Journal of the American Heart Association · 2021Observational
- A comparative 30-day outcome analysis of inpatient evaluation vs outpatient testing in patients presenting with chest pain in the high-sensitivity troponin era. A propensity score matched case-control retrospective study.Clinical cardiology · 2020Article
- Comparative outcome analysis of stable mildly elevated high sensitivity troponin T in patients presenting with chest pain. A single-center retrospective cohort study.International journal of cardiology. Heart & vasculature · 2020Article
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- Emergency department routine data and the diagnosis of acute ischemic heart disease in patients with atypical chest pain.PloS one · 2020Article
- Artificial intelligence to predict needs for urgent revascularization from 12-leads electrocardiography in emergency patients.PloS one · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Thrombolysis in Myocardial Infarction (TIMI) risk score uses clinical data to predict the short-term risk of acute myocardial infarction, coronary revascularization or death from any cause. It was originally developed for use in patients with unstable angina or non-ST-elevation myocardial infarction. We sought to expand the clinical application of the TIMI risk score by assessing its prognostic accuracy in patients in the emergency department with potential acute coronary syndromes.
methodsWe searched five electronic databases, hand-searched reference lists of included studies and contacted content experts to identify articles for review. We included prospective cohort studies that validated the TIMI risk score in emergency department patients. We performed a meta-regression to determine whether a linear relation exists between TIMI risk score and the cumulative incidence of cardiac events.
resultsWe included 10 prospective cohort studies (with a total of 17 265 patients) in our systematic review. Data were available for meta-analysis in 8 of the 10 studies. Of patients with a score of zero, 1.8% had a cardiac event within 30 days (sensitivity 97.2%, 95% CI 96.4-97.8; specificity 25.0%, 95% CI 24.3-25.7; positive likelihood ratio 1.30, 95% CI 1.28-1.31; negative likelihood ratio 0.11, 95% CI 0.09-0.15). Meta-regression analysis revealed a strong linear relation between TIMI risk score (p < 0.001) and the cumulative incidence of cardiac events.
interpretationAlthough the TIMI risk score is an effective risk stratification tool for patients in the emergency department with potential acute coronary syndromes, it should not be used as the sole means of determining patient disposition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.